Pari CR 12.5 Tablet

Pari CR 12.5 Tablet

Prescription: Required
Manufacturer: Ipca Laboratories Ltd
SALT COMPOSITION: Paroxetine (12.5mg)
Storage: Store below 30°C

CR: Controlled Release

Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of premature ejaculation and hot flashes due to menopause. It is taken by mouth.

Common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, and sexual dysfunction. Serious side effects may include suicidal thoughts in those under the age of 25, serotonin syndrome, and mania. While the rate of side effects appears similar compared to other SSRIs and SNRIs, antidepressant discontinuation syndromes may occur more often. Use in pregnancy is not recommended, while use during breastfeeding is relatively safe. It is believed to work by blocking the re-uptake of the chemical serotonin by neurons in the brain.

Paroxetine was approved for medical use in the United States in 1992 and initially sold by GlaxoSmithKline. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2019, it was the 78th most commonly prescribed medication in the United States, with more than 9 million prescriptions. In 2018, it was in the top 10 of most prescribed antidepressants in the United States. In 2012, the United States Department of Justice fined GlaxoSmithKline $3 billion for withholding data, unlawfully promoting use in those under 18, and preparing an article that misleadingly reported the effects of paroxetine in adolescents with depression following its clinical trial study 329.



IUPAC name
(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine

Introduction

Pari CR 12.5 Tablet is a type of antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) group of medicines. It is widely prescribed to treat depression and anxiety-related conditions like obsessive-compulsive disorder, and panic disorder.

Pari CR 12.5 Tablet helps many people to recover from depression by improving their mood and relieving anxiety and tension. It can be taken with or without food. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms.

Your doctor may start you on a lower dose and increase it gradually. Do not change the dose or stop taking it without talking to your doctor, even if you feel well. Doing so may make your condition worse or you may suffer from unpleasant withdrawal symptoms (anxiety, restlessness, palpitations, dizziness, sleep disturbances, etc).

To get the most benefit, take this medicine regularly at the same time each day. Your doctor may advise you to take it in the morning if you have trouble sleeping. It may take a few weeks before you start feeling better. Let your doctor know if you do not see any improvement even after 4 weeks.

Some common side effects of Pari CR 12.5 Tablet include nausea, fatigue, dry mouth, loss of appetite, increased sweating, dizziness, nervousness, tremors, insomnia (difficulty in sleeping), and constipation. Sexual side effects like decreased sexual drive, delayed ejaculation, and erectile dysfunction may also be seen. Let your doctor know straight away if you develop any sudden worsening of mood or any thoughts about harming yourself.

Before taking this medicine, you should tell your doctor if you have epilepsy (seizure disorder or fits), diabetes, liver or kidney disease, heart problems, or glaucoma. These may affect your treatment. Pregnant or breastfeeding women should also consult their doctor before taking it. Some other medicines may affect the way it works, especially other antidepressants and medicines called MAO inhibitors. Please tell your doctor about all the medicines you are taking to make sure you are safe.

Uses of Pari Tablet CR

1. Treatment of Depression
2. Treatment of Panic disorder
3. Treatment of Anxiety disorder

Benefits of Pari Tablet CR

In Treatment of Depression
Pari CR 12.5 Tablet works by increasing the level of a chemical called serotonin in the brain. This improves your mood, relieves anxiety, tension, and helps you sleep better. It has fewer side effects than older antidepressants. It usually takes 4-6 weeks for this medicine to work so you need to keep taking it even if you feel it is not working. Do not stop taking it, even if you feel better unless your doctor advises you to.

In Treatment of Panic disorder
Pari CR 12.5 Tablet can help relieve symptoms of many panic disorders including panic attacks. It can help you feel calmer and improve your ability to deal with problems. Do not stop taking it, even when you feel better, unless your doctor advises you to.

In Treatment of Anxiety disorder
Pari CR 12.5 Tablet helps relieve symptoms of many anxiety disorders including obsessive-compulsive disorder and generalized anxiety disorder by increasing the level of a chemical called serotonin in your brain. It has fewer side effects than older antidepressants and is normally taken once a day. It helps you feel calm with a better ability to deal with problems. Exercise and a healthy diet can also improve your mood. Keep taking the medicine until your doctor advises you to stop.

Side effects of Pari Tablet CR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them:
Common side effects of Pari:

1. Nausea
2. Fatigue
3. Dryness in mouth
4. Loss of appetite
5. Increased sweating
6. Dizziness
7. Nervousness
8. Tremor
9. Low sexual desire
10. Insomnia (difficulty in sleeping)
11. Confusion
12. Constipation
13. Erectile dysfunction
14. Delayed ejaculation
15. Decreased libido

How Pari CR works

Pari CR 12.5 Tablet is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of panic disorder, anxiety, and obsessive-compulsive disorder.

Quick tips
1. It can take 2-3 weeks for Pari CR 12.5 Tablet to start working.
2. Do not stop treatment suddenly as this may cause upset stomach, flu-like withdrawal symptoms and sleep disturbance.
3. If your doctor asks you to stop Pari CR 12.5 Tablet, you should reduce the dose slowly over 4 weeks.
4. Avoid consuming alcohol when taking Pari CR 12.5 Tablet, as it may cause excessive drowsiness and calmness.
5. The addiction/dependence potential of Pari CR 12.5 Tablet is very less. 

Interaction with drugs

Taking Pari with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Linezolid
Brand(s): Lizolan, Lidoford, Zenlid
LIFE-THREATENING

Moclobemide
Brand(s): Trima, Rimarex, Morex
LIFE-THREATENING

Rasagiline
Brand(s): Rasalect, Relgin, Rasipar
LIFE-THREATENING

Reboxetine
Brand(s): Rebotin
LIFE-THREATENING

Fact Box

Chemical Class: Phenylpiperidine Derivative
Habit Forming: No
Therapeutic Class: NEURO CNS
Action Class: Selective Seretonin Reuptake inhibitors (SSRIs)

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