Wednesday, April 14, 2021

Folliserum Ingredients (Apr 2021)



1. Aqua
Aqua: water, when it is used in make-up and beauty products

2. Butylene glycol

Butylene glycol is a chemical ingredient used in self-care products like:

2.1. shampoo
2.2. conditioner
2.3. lotion
2.4. anti-aging and hydrating serums
2.5. sheet masks
2.6. cosmetics
2.7. sunscreen

Butylene glycol is included in formulas for these types of products because it adds moisture and conditions hair and skin. It also works as a solvent, meaning it keeps other ingredients, dyes, and pigments from clumping up inside of a solution.

Like all glycols, butylene glycol is a type of alcohol. It’s often made from distilled corn.

There are some health concerns that surround the use of butylene glycol. Some experts warn against its use, and cite it on lists of ingredients to avoid when choosing self-care products.

The risk in using butylene glycol is still somewhat unclear. More research is needed to understand how it can affect your body in the long term.
Butylene glycol uses

Butylene glycol is added to all kinds of products that you apply topically. It’s particularly popular in clear gel-based products and in makeup that glides onto your face.

You’ll find it on the ingredients list of sheet masks, shampoos and conditioners, eye liners, lip liners, anti-aging and hydrating serums, tinted moisturizers, and sunscreens.
Butylene glycol is a viscosity-decreasing agent

“Viscosity” is a word that refers to how well things stick together, particularly in a compound or chemical mixture. Butylene glycol makes other ingredients less likely to stick together, giving makeup and self-care products a fluid and even consistency.
Butylene glycol is a conditioning agent

Conditioning agents are ingredients that add a layer of softness or improved texture to your hair or skin. They’re also called moisturizers or, in the case of butylene glycol, humectants. Butylene glycol works to condition skin and hair by coating the surface of your cells.
Butylene glycol is a solvent

Solvents are ingredients that maintain a liquid consistency in a chemical compound. They help active ingredients that could become gritty or clumpy stay dissolved. Butylene glycol keeps the ingredients in cosmetics spread out and in their desired state for use.
Butylene glycol benefits

Butylene glycol has some health benefits if you have dry skin on your face or frequent breakouts. But it won’t work the same way for every person. Generally, most people who have dry skin can use products with butylene glycol to reduce their symptoms.
Butylene glycol for acne

Butylene glycol is in some moisturizersTrusted Source made for people who have acne. It isn’t the active ingredient that treats acne in these products. The moisturizing and solvent properties in butylene glycol could make these products right for you.

However, there are reports of this ingredient clogging pores or irritating skin and actually making acne worse.

Based on your symptoms, the cause of your acne, and your skin sensitivity, butylene glycol may be an ingredient that works in your skin care regimen.

Ref: healthline

3. ppg-26-buteth-26

What Is It?

Polypropylene Glycol (PPG) Buteths (PPG-12-Buteth-16, PPG-9-Buteth-12, PPG-26-Buteth-26, PPG-28-Buteth-35) are colorless or pale yellow, transparent liquids. In cosmetics and personal care products, PPG Buteth ingredients are used in the formulation of bubble baths and other bath products, shampoos and other hair products, skin fresheners, skin cleansers, and shaving products.

Why is it used in cosmetics and personal care products?

PPG Buteth ingredients enhance the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment. They also enhance the appearance of dry or damaged skin by reducing flaking and restoring suppleness. PPG Buteths help to form emulsions by reducing the surface tension of the substances to be emulsified. PPG-12-Buteth-16 can also be used to dissolve other substances, usually liquids.
Scientific Facts: 

PPG Buteth ingredients are synthetic polymers prepared from small chemical compounds called monomers. PPG Buteths are made from equal amounts ethylene oxide and propylene oxide monomers, and the reaction is initiated by the addition of butyl alcohol. The first number in the name indicates the average number of units of propylene oxide, while the second number indicates the average number of units of ethylene oxide.

Ref: cosmeticsinfo

4. PEG 40 Hydrogenated Castor Oil

WHAT IS PEG 40 HYDROGENATED CASTOR OIL?

PEG 40 Hydrogenated Castor Oil is the Polyethylene Glycol derivatives of Hydrogenated Castor Oil, and it functions as a surfactant, a solubilizer, an emulsifier, an emollient, a cleansing agent, and a fragrance ingredient when added to cosmetics or personal care product formulations. NDA’s PEG 40 Hydrogenated Castor Oil is a semi-solid ingredient.

surfactant: a substance which tends to reduce the surface tension of a liquid in which it is dissolved.

solubilizer: an agent that increases the solubility of a substance.

emulsifier: An emulsifier is an additive which helps two liquids mix. For example, water and oil separate in a glass, but adding an emulsifier will help the liquids mix together. Some examples of emulsifiers are egg yolks and mustard.

emollient: Emollients are substances that soften and moisturize the skin and decrease itching and flaking. 

HOW DOES PEG 40 HYDROGENATED CASTOR OIL WORK?

PEG-40 Hydrogenated Castor Oil is soluble in both water and oil and is traditionally used to emulsify and solubilize oil-in-water formulations. Its foam-enhancing properties make it ideal for use in liquid cleansers, and its soothing and softening emollient quality makes it a popular addition to formulations for moisturizers and hair care cosmetics. As a surfactant, PEG 40 Hydrogenated Castor Oil helps to decrease the surface tension between multiple liquids or between liquids and solids. Furthermore, it helps to remove the grease from oils and causes them to become suspended in the liquid. This makes it easier for them to be washed away and lends this ingredient popularity in facial and body cleansers. As an occlusive agent, PEG 40 Hydrogenated Castor Oil creates a protective hydrating layer on the skin’s surface, acting as a barrier against the loss of natural moisture.

Ref: newdirectionsaromatics

5. Apigenin

One of the bioflavonoids, apigenin appears to be catered towards reducing anxiety and causing sedation. Found in chamomile tea, alcoholic beverages, and Bacopa Monnieri, apigenin is unstable by itself yet stable when consumed via foods and herbs. [Ref: examine]

The Therapeutic Potential of Apigenin

Chronic diseases, such as cancer, stroke, diabetes, Alzheimer’s disease, depression, and age-related function decline, are major public health burdens worldwide, especially in developed countries. It is believed that a combination of regular physical activity and healthy diet can prevent these various diseases, as well as help in fighting already existing diseases. Particular attention has been paid to a diet based on fruits and vegetables, which are sources of natural bioactive compounds with pro-health properties. The largest group of naturally-occurring polyphenols are the flavonoids, which include flavones, flavonols, flavanones, flavanols, isoflavonoids, and anthocyanidins. Flavonoids are characterized by broad biological activities, demonstrated in numerous mammalian systems in vitro and in vivo. These compounds act as free-radical scavengers and antioxidants, exhibiting anti-mutagenic, anti-inflammatory, and antiviral effects. What is more, flavonoids are able to reduce plasma levels of low-density lipoproteins, inhibit platelet aggregation, and reduce cell proliferation. These properties result, inter alia, from their mechanisms of action: inhibiting the cell cycle, diminishing oxidative stress, improving detoxification enzymes, inducing apoptosis, and stimulating the immune system. Of all the flavonoids, apigenin (4′,5,7-trihydroxyflavone) is one of the most widely distributed in the plant kingdom, and one of the most studied phenolics. Apigenin is present principally as glycosylated in significant amount in vegetables (parsley, celery, onions) fruits (oranges), herbs (chamomile, thyme, oregano, basil), and plant-based beverages (tea, beer, and wine). The present review is focused on the health-promoting effects of apigenin, in particular through in vivo research.

Ref:  US National Library of Medicine; National Institutes of Health 

Chemically:
Apigenin (4′,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. It is a yellow crystalline solid that has been used to dye wool. [Ref: Wikipedia]

6. Oleanolic acid

Oleanolic acid is relatively non-toxic, hepatoprotective, and exhibits antitumor and antiviral properties.

Oleanolic acid was found to exhibit weak anti-HIV and weak anti-HCV activities in vitro, but more potent synthetic analogs are being investigated as potential drugs.

An extremely potent synthetic triterpenoid analog of oleanolic acid was found in 2005, that is a powerful inhibitor of cellular inflammatory processes. They work by the induction by IFN-γ of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages. They are extremely potent inducers of the phase 2 response (e.g., elevation of NADH-quinone oxidoreductase and heme oxygenase 1), which is a major protector of cells against oxidative and electrophile stress.

A 2002 study in Wistar rats found that oleanolic acid reduced sperm quality and motility, causing infertility. After withdrawing exposure, male rats regained fertility and successfully impregnated female rats.

[Ref: Oleanolic acid]

Oleanolic acid is a pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3. It has a role as a plant metabolite. It is a pentacyclic triterpenoid and a hydroxy monocarboxylic acid. It is a conjugate acid of an oleanolate. It derives from a hydride of an oleanane.

Ref: National Center for Biotechnology Information; National Library of Medicine; National Institutes of Health; Department of Health and Human Services; USA.gov

7. Biotinoyl Tripeptide-1

What-it-does: cell-communicating ingredient 

A three amino acid peptide where the famous collagen fragment, Tripeptide-1, aka GHK is combined with Biotin, the well-known supplement for stronger nails and hairs. The result of the combination is Biotinoyl Tripeptide-1, a peptide claimed to be helpful for reducing hair loss and for making the eyelashes appear longer, fuller, and stronger.

As for proof, the manufacturer did some in-vitro (made in test tubes) studies that show that our molecule can promote hair bulb keratinocyte proliferation and also helps optimal hair anchorage by stimulating the synthesis and organization of the adhesion molecules laminin 5 and collagen IV. This means that our peptide might help the hair to be stronger and to stay longer in its place, though these are only in vitro results that might or might not translate to real-world use. 

Ref: incidecoder

8. Polysorbate 20

Polysorbate 20 is an ingredient used in skincare and cosmetic formulations to improve the texture, feel, and scent of the product. It is mainly used as a surfactant, emulsifier, and fragrance ingredient. 

Polysorbate 20, also listed on an ingredient label as Tween 20, is formed by the ethoxylation of sorbitan before the addition of lauric acid. The process of making polysorbate 20 begins with sorbitol, a sugar alcohol that can naturally be found in some fruits. The dehydration of sorbitol results in sorbitan. The next step in the process of making polysorbate 20 is ethoxylation, which is a chemical reaction in which ethylene oxide is added to a substrate, in this case, sorbitan. Thus, sorbitan is reacted with 20 units of ethylene oxide, giving polysorbate 20 its name. The final step is the addition of one lauric acid group.

Polysorbate 20 is used in a variety of cosmetics and skincare products including cleansers, makeup bases and foundations, shampoos, fragrances, and more. This ingredient exists in the form of a clear to a light yellow viscous liquid.

Ref: thedermreview

9. Glycerin

Behind water and fragrance, glycerin is the third most frequently reported ingredient in cosmetics, according to a 2014 Cosmetic Ingredient Review.

Recognized as a major ingredient in moisturizers and lotions, buying and using glycerin in its pure form is growing in popularity.

Studies show that glycerin can positively affect your skin in a number of ways. Keep reading to find out how.
Glycerin and your skin

Glycerin’s appearance in skin care products appears to be warranted.

According to a 2008 study, glycerin can:

9.1. hydrate the outer layer of the skin (stratum corneum)
9.2. improve skin barrier function and skin mechanical properties
9.3. provide protection against skin irritants
9.4. accelerate wound-healing processes 

Ref: healthline

10. PEG-12 Dimethicone

PEG-12 Dimethicone is a silicone glycol copolymer that is soluble in water, alcohol, and hydro-alcoholic systems. It acts as a surface tension depressant, wetting agent, emulsifier and foam builder to create and sustain foam in a high alcohol-content hand sanitizer formulations. PEG-12 Dimethicone is also used in in a wide variety of cosmetic and personal care products, including, hair sprays, shampoos, skin care, lotions, perfumes and shaving soaps, to create and sustain foam. 

Ref: clearcoproducts

11. Polyquaternium-22

Polyquaternium is the International Nomenclature for Cosmetic Ingredients designation for several polycationic polymers that are used in the personal care industry. Polyquaternium is a neologism used to emphasize the presence of quaternary ammonium centers in the polymer. INCI has approved at least 40 different polymers under the polyquaternium designation. Different polymers are distinguished by the numerical value that follows the word "polyquaternium". Polyquaternium-5, polyquaternium-7, and polyquaternium-47 are three examples, each a chemically different type of polymer. The numbers are assigned in the order in which they are registered rather than because of their chemical structure.

Polyquaterniums find particular application in conditioners, shampoo, hair mousse, hair spray, hair dye, personal lubricant, and contact lens solutions. Because they are positively charged, they neutralize the negative charges of most shampoos and hair proteins and help hair lie flat. Their positive charges also ionically bond them to hair and skin. Some have antimicrobial properties. 

Ref: Polyquaternium

12. Niacinamide

What is Niacinamide?
Niacinamide is a water soluble-form of vitamin B3 that has many benefits suited to any and all skin and hair types.

Niacinamide benefits

Niacinamide is an antioxidant and anti-inflammatory ingredient. It can help brighten and refresh skin and hair by helping to retain moisture. It can also help regulate oil for more refreshed and balanced-feeling scalp and skin.

Niacinamide for hair

Niacinamide has a vital role in growing long and strong hair due to its circulation boosting properties. It enhances the appearance and feel of hair, by increasing body, suppleness, sheen. It also improves the texture of hair that has been physically/chemically damaged by helping to build Keratin. It also enhances the appearance of dry or damaged skin on the scalp by reducing flaking and restoring suppleness.

Ref: growgorgeous

13. Helianthus Annuus (Sunflower) Seed Extract

Sunflower oil benefits for hair and skin: (helianthus annuus):

Besides being a beautiful gift of nature and used passionately by artists, sunflowers contain significant properties for great skin and hair.

Rich in nutrients such as calcium, iron, magnesium, zinc and vitamins A, K and E, it’s used effectively against inflammation and general irritations of the skin. Being very high in vitamin E, it acts as an emollient which traps moisture and keeps skin well hydrated. It also helps prevent damage to cells by ultraviolet light and aids against premature aging of skin by protecting the collagen and elastin content.

Sunflower is a source for beta-carotene which is converted to vitamin A with benefits of protection from sun damage and free radicals. Omega-6 (linoleic acid) which is found in sunflower oil, assists with cell development and treating disorders such as eczema, acne and scarring.

A number of characteristics make sunflower oil also beneficial for hair. The linoleic acid it contains assists with slowing hair loss. The menthol assists with dandruff control while its antibacterial properties help keep the scalp microbial free. Its emollient properties keep hair soft, moist and assist with untangling.

So when driving by a gorgeous field of sunflowers on a European Summer or see an old man chipping away on sunflower seeds in a village, remember the positive effects it has on our bodies for health and protection.

Aeolis uses sunflower oil in its body lotions, hand cream, hair conditioner, hair mask and anti-wrinkle lifting face cream.

Ref: aeolisskincare

14. Pea Protein Powder

Pea protein powder is a supplement made by extracting protein from yellow peas.

It’s typically used to increase the protein content of smoothies and shakes and is a great fit for almost any diet since it’s naturally vegan and hypoallergenic.

Pea protein is a high-quality protein and a great source of iron. It can aid muscle growth, weight loss and heart health.

This article reviews the nutrition, health benefits and possible side effects of pea protein powder.

Pea protein powder — or pea protein isolate — is made by isolating the protein from ground yellow peas, forming a beige powder.

Nutrition facts can vary between brands, but — for example — two scoops (20 grams) of NOW Organic Pea Protein Powder contains:

14.1. Calories: 80
14.2. Protein: 15 grams
14.3. Carbs: 1 gram
14.4. Fiber: 1 gram
14.5. Total fat: 1.5 grams
14.6. Sodium: 230 mg
14.7. Iron: 5 mg

Pea protein powders offer a variety of nutritional benefits.

Ref: healthline

15. PEG-8

What-it-does: moisturizer/humectant, solvent 

A smallish polymer molecule (created from repeated units of Polyethylene glycol, aka PEG) that's used as a solubilizer and viscosity control agent.

It is a clear, colorless liquid that is water-soluble and water-binding (aka humectant) and can help to solubilize sparingly-water soluble things (e.g. vanilla, perfumes) into water-based formulas. Thanks to its water-binding ability, it also prevents the drying out of formulas, especially when combined with the fellow hygroscopic agent, sorbitol. 

Ref: incidecoder

16. PEG-8/SMDI COPOLYMER

17. PALMITOYL MYRISTYL SERINATE

Palmitoyl Myristyl Serinate is a product obtained by the condensation of Palmitic Acid (q.v.)with Serine (q.v.), followed by esterification with Myristyl Alcohol (q.v.).

Skin-conditioning agent: miscellaneous and skin conditioning

Ref: ewg.org

18. Sodium polyacrylate

Sodium polyacrylate (also called acrylic sodium salt polymer) is a superabsorbent polymer that is used extensively in commercial applications as a water absorbent. It is a white, granular, odorless solid that is not considered hazardous. Sodium polyacrylate is made when a mixture of acrylic acid and sodium acrylate is polymerized.

Ref: sciencing

Sodium polyacrylate is an absorbent polymer that is used as an emulsion stabilizer, a hair fixative, a film former, skin conditioner, and a viscosity agent. You will see them as the gel like crystals in baby diapers, which are makes them  absorbent. In detergents it works as a chelating agent, which neutralizes the heavy metals in water & dirt so that the detergent can be more effective at cleaning. It is also used as a thickening agent because it can absorb and hold onto water molecules. 

Ref: forceofnatureclean

19. Adenosine

Adenosine in the brain

In the brain adenosine is an inhibitory neurotransmitter. This means, adenosine can act as a central nervous system depressant. In normal conditions, it promotes sleep and suppresses arousal. When awake the levels of adenosine in the brain rise each hour.

Adenosine in the heart
In the heart adenosine causes dilation of the coronary blood vessels that improves blood circulation to the heart. Adenosine also increases the diameter of blood vessels in the peripheral organs.

In the heart adenosine decreases heart rate and in blood it has an anti-platelet action. Antiplatelet action prevents platelet aggregation and coagulation.

Adenosine in the kidneys, lungs and liver
In the kidneys, adenosine decreases renal blood flow and decrease the production of rennin from the kidneys.

In the lungs, it causes constriction of airways and in the liver it leads to constriction of blood vessels and increases breakdown of glycogen to form glucose.

Ref: Adenosine

20. Phenoxyethanol

Why is it added to cosmetics?

In perfumes, fragrances, soaps, and cleansers, phenoxyethanol works as a stabilizer. In other cosmetics, it’s used as an antibacterial and/or a preservative to prevent products from losing their potency or spoiling.

When combined with another chemical, some evidence indicates that it’s effective at reducing acne. One 2008 study on 30 human subjects with inflammatory acne showed that after six weeks of twice-daily applications, more than half of the subjects saw a 50 percent improvement in their number of pimples.

Manufacturers who want to avoid using parabens, which have recently lost favor among health-conscious consumers, might use phenoxyethanol in their products as a substitute.

But is phenoxyethanol safer than parabens for topical use in humans?

Ref: healthline

21. Ethylhexylglycerin

Ethylhexylglycerin is a globally approved, versatile and multifunctional additive as well as a very effective deodorant active. As an emollient and mild humectant it improves the skin feel of cosmetic formulations.
It reliably inhibits the growth and multiplication of odour-causing bacteria, while at the same time not affecting the beneficial skin flora. Additionally, it can boost the efficacy of traditional preservatives and acts as an antimicrobial stabiliser in combination with other cosmetic ingredients.

Ref: ethylhexylglycerin

22. Cocos Nucifera oil

There is definitely some craze going on for coconut oil both in the healthy eating space (often claimed to be the healthiest oil to cook with but this is a topic for another site) and in the skin and hair care space. 

We will talk here about the latter two and see why we might want to smear it all over ourselves. Chemically speaking, coconut oil has a unique fatty acid profile. Unlike many plant oils that mostly contain unsaturated fatty acids (fatty acids with double bonds and kinky structure such as linoleic or oleic), coconut oil is mostly saturated (fatty acids with single bonds only) and its most important fatty acid is Lauric Acid (about 50%).  Saturated fatty acids have a linear structure that can stack nice and tight and hence they are normally solid at room temperature. Coconut oil melts around 25 °C so it is solid in the tub but melts on contact with the skin. 
Ref: incidecoder

23. Hydroxyethyl cellulose

Hydroxyethyl cellulose is a gelling and thickening agent derived from cellulose. It is widely used in cosmetics, cleaning solutions, and other household products. Hydroxyethyl cellulose and methyl cellulose are frequently used with hydrophobic drugs in capsule formulations, to improve the drugs' dissolution in the gastrointestinal fluids. This process is known as hydrophilization.

Hydroxyethyl cellulose is also used extensively in the oil & gas industry as a drilling mud additive under the name HEC as well in industrial applications, paint & coatings, ceramics, adhesives, emulsion polymerization, inks, construction, welding rods, pencils and joint fillers.

Hydroxyethyl cellulose is one of the main ingredients in the personal lubricant KY Jelly. It is also a key ingredient in the formation of big bubbles as it possesses the ability to dissolve in water but also provide structural strength to the soap bubble. Among other similar chemicals, it is often used as slime (and gunge, in the UK), a gooey substance often used on television and in fundraising events which is poured over individuals with the aim of causing embarrassment. 

Ref: Hydroxyethyl cellulose

24. Melatonin

Melatonin is a hormone found naturally in the body. Melatonin used as medicine is usually made synthetically in a laboratory. It is most commonly available in pill form, but melatonin is also available in forms that can be placed in the cheek or under the tongue. This allows the melatonin to be absorbed directly into the body.

Some people take melatonin by mouth to adjust the body's internal clock. Melatonin is most commonly used for insomnia and improving sleep in different conditions. For example, it is used for jet lag, for adjusting sleep-wake cycles in people whose daily work schedule changes (shift-work disorder), and for helping people establish a day and night cycle.

Coronavirus disease 2019 (COVID-19): There is no good evidence to support using melatonin for COVID-19. Follow healthy lifestyle choices and proven prevention methods instead.

How does it work?
Melatonin's main job in the body is to regulate night and day cycles or sleep-wake cycles. Darkness causes the body to produce more melatonin, which signals the body to prepare for sleep. Light decreases melatonin production and signals the body to prepare for being awake. Some people who have trouble sleeping have low levels of melatonin. It is thought that adding melatonin from supplements might help them sleep.

Ref: webmd

25. Disodium EDTA

A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.

Chelating: A chemical compound that binds tightly to metal ions. In medicine, chelating agents are used to remove toxic metals from the body.

Ref: pubchem.ncbi.nlm.nih.gov

26. Cholecalciferol

Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D which is made by the skin when exposed to sunlight; it is also found in some foods and can be taken as a dietary supplement.

Cholecalciferol is made in the skin following UVB light exposure. It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25-dihydroxyvitamin D). One of its actions is to increase the uptake of calcium by the intestines. It is found in food such as some fish, beef liver, eggs, and cheese. Certain foods such as milk, fruit juice, yogurt, and margarine also may have cholecalciferol added to them in some countries including the United States.

Cholecalciferol can be taken as an oral dietary supplement to prevent vitamin D deficiency or as a medication to treat associated diseases, including rickets. It is also used for familial hypophosphatemia, hypoparathyroidism that is causing low blood calcium, and Fanconi syndrome. Vitamin-D supplements may not be effective in people with severe kidney disease.[9][8] Excessive doses in humans can result in vomiting, constipation, weakness, and confusion. Other risks include kidney stones. Doses greater than 40,000 IU (1,000 μg) per day are generally required before high blood calcium occurs. Normal doses, 800–2000 IU per day, are safe in pregnancy.

Cholecalciferol was first described in 1936. It is on the World Health Organization's List of Essential Medicines. Cholecalciferol is available as a generic medication and over the counter. Cholecalciferol is also used at much higher doses to kill rodents.

Ref: Cholecalciferol

Vitamin D (ergocalciferol-D2, cholecalciferol-D3, alfacalcidol) is a fat-soluble vitamin that helps your body absorb calcium and phosphorus. Having the right amount of vitamin D, calcium, and phosphorus is important for building and keeping strong bones. Vitamin D is used to treat and prevent bone disorders (such as rickets, osteomalacia). Vitamin D is made by the body when skin is exposed to sunlight. Sunscreen, protective clothing, limited exposure to sunlight, dark skin, and age may prevent getting enough vitamin D from the sun.Vitamin D with calcium is used to treat or prevent bone loss (osteoporosis). Vitamin D is also used with other medications to treat low levels of calcium or phosphate caused by certain disorders (such as hypoparathyroidism, pseudohypoparathyroidism, familial hypophosphatemia). It may be used in kidney disease to keep calcium levels normal and allow normal bone growth. Vitamin D drops (or other supplements) are given to breast-fed infants because breast milk usually has low levels of vitamin D.

Ref: webmd

Other Notes

Folliserum: 60 ML bottle lasts for lesser than a month and costs around 1200 INR as in Mar 2021.

Tuesday, April 13, 2021

March 06, 2008



Index of Journals
Thursday, 6 March 2008

Hi Buddy! How are you? Hmmm... Kaisi hai?

As usual, I woke up at 4AM (viz 9AM for me). Took the full tension for Chemistry exam on the head and started planning for the day.

"DO ANYTHING BUT DON'T WASTE TIME"

My motto: Only for saying it without meaning it ;)

Sometime really interesting happened in the morning... A song by Atif Aslam was playing on the FM and aunt (chachi) as usual came and pulled out the plug.

Nobody knows what's going on in her mind and the problem with her! 

Today in 2021: I realize that it is a kind of sensitization process.

Anu came out frustrated this time and said "Why do you always shut off FM at this song? Lallu ho kya? (English: Are you lallu?)"

My innerself burst into laughter... Aunt questioned her "what did she say?" and then said "Is that the way to speak?"

I to myself: Aunt, please do not joke!

Burst water balloons in the evening. Really fun. Raju's younger brother, Sonal, Srishti and Mreeganka were running like ants on the ground. Also burst on Ganpat (Anushka's (Kukku) driver). He came up on the roof with the security guard. What could he have uprooted by doing that?

When he went down again, I again aimed balloons at him. When we (Amogh, Appu and I) went down we say him complaining at my home and later he complained to Amogh's father also. What was to happen, huh! Amogh's father said, "It is Holi festival. Go on." And nobody asked me about it at home. So stay cool! Chemistry Part-1 is almost complete (reading). Only Equilibrium is left that I will complete tomorrow morning (4AM). It's 12:10 and I am going to brush my teeth as chewing gum has accelerated the formation of dental biofilm (plaque) on my teeth.

Bye.
See you.

Ashish Jain
!MPoSS!BlE
God Bless 'Me'

Sunday, April 11, 2021

March 05, 2008



Index of Journals
Wednesday, March 5, 2008

Forgot to give the report card even today (on the day of second last year-end examination).

Had taken God's name before sleeping last night that's why exam today went good. Mind it... Good and not okay... 
Okay, I hope I will get over 40 out of 70... just hoping for such result and not sure about it. God will bless me... Met Amogh in the morning and Sonal was standing at her place (Hahaha :D) 

Today I left without chewing gum as the teacher would have, then, asked me to spit out... 

5:15 AM: woke up but then I slept again because I have been in tension by studying at the last moment. Woke up at 7:10 in full tension... but Amogh's blessings and wishes came to the rescue and Amma (grand mother) also didn't forget to put holy-sand on me.

Around 12:30 (when Dimpi used to come) I went out to leave for Manju buaji's house. There I saw movie and TV till 6 PM. Yes, yes and talked to her a little bit. Am not that bad. First, I ate Anu's Dairy milk and then took her KitKat for Prachi. 
Also played soccer today, had fun.
Mreeganka was ignoring me: "Chalo yaar, yahaan se chalo. Chalo yaar, yahaa se chalo." (In English: Let's go from here) 
I don't even pay attention to her, damn girl! 

Went to terrace after soccer and then back at home at 9 PM (9:15).

Passing some time right now. 
Gotta go for some study for some time. It is not a joke. Need to study a little bit.

God Bless 'Me'
Ashish Jain
!MPoSS!BlE

March 03, 2008



Index of Journals
Monday, March 3, 2008

Beginning of the day was okay but ending was a complete flop!

Woke up at 4 AM to turn off the alarm and slept again and later woke up at 7:30, saw Sonal waiting for the bus from the window. The bus got late by 15 minutes and because of that I had been thinking that she missed the bus on the day of her exam that was making me feel so happy. For around half-an-hour, I talked to Amogh. He gave me three chewing gums... fun... quota for 2-3 weeks complete. Weather was okay the whole day and my mood too. Studies also went on at okay pace. In the evening Srishti asked Sonal and Dimpi to sit in the drawing room and wait for her. She came into my room and said, "Go. Dimpi is sitting outside and Sonal too." I said call them in (here). She called them when they reached the door she said, "You too sit with Ashish." I said, "What 'sit with Ashish'?" and lost that very good chance to be with them. :(
    
At 7 PM, I went to play, it was fun. Ask me, "when do I don't enjoy playing" ;) 

Studied till 12 PM on coming back home. Course still left. Shall study tomorrow.

News of the day: I saw Mehee aunty (Sonal's mother) in the morning when she was there to get vegetables and in the evening Srishti told me that Sonal is going to wear 'Salwar' in 9th standard. Does that mean they aren't going anywhere (New Zealand)? :D

God Bless 'Me'
Ashish Jain
!MPoSS!BlE

March 04, 2008



Index of Journals
Tuesday, Mar 4, 2008

Chachaji (younger brother of father) asked me what is "Buffalo's eye". That's in the morning, and what he read from the entry of 1st March. I doubt Prashant for all this. He must have made him read that. I was speechless. Anu came to the "rescue" and said "it was (a line) used in the movie Munna Bhai MBBS." Thank God! He also questioned me about what I wrote about Dimpi (you know).

~ ~ ~

I woke up at 4:00 AM this morning to study. I went to the temple today. Whole day passed in preparing myself for the exam that is going to be held tomorrow (Physics).

No amount of preparation is enough... so is the case with this subject.

But still I put my best effort to score better... else is in god's hands! :|

Went to play outside in the afternoon and also watched India vs Australia. India won the match. It was cool!

Srishti said she taunts Mreeganka by saying that she likes me. And asked her why does she look at me seriously. Man! It is not like that over here; this side. And Mreeganka isn't my choice. Well, gotta go. 

See you. Will count beads (Japamala) now.
Wish me 'Best of Luck'.

Ashish Jain
!MPoSS!BlE

A Japamala or mala (Sanskrit; meaning 'garland') is a string of prayer beads commonly used in Hinduism, Jainism, Sikhism, Buddhism, and other traditions for the spiritual practice known in Sanskrit as japa. They are similar to other forms of prayer beads used in various world religions and sometimes referred to in English as a "rosary". [Ref: Wikipedia]

Are NSAIDs bad for liver and kidney?



How much ibuprofen can I take?
To treat mild to moderate pain, minor fever, and acute or chronic inflammation, 200 mg to 400 mg of ibuprofen will work. That amount is comparable to 650 mg of acetaminophen (Tylenol) or aspirin.

Generally, the maximum amount of NSAIDs you should take per day is 3200 mg or 12 over-the-counter tablets. That means if you take a dose every 6 hours, you can take up to 800 mg each time.

- - -

Can ibuprofen cause liver damage?

Ibuprofen and other NSAIDs rarely affect the liver. Unlike acetaminophen (Tylenol), most NSAIDs are absorbed completely and undergo negligible liver metabolism.

In other words, the way NSAIDs are metabolized makes liver injury ( hepatotoxicity) very rare. Estimates are that 1 to 9 in 100,000 NSAID prescriptions result in acute liver injury. Generally, NSAIDs are very liver-safe.

However, if you have problems with your liver, such as cirrhosis, talk to your doctor before taking NSAIDs. Also, studies have shown NSAIDs can cause elevated results on liver tests in up to 15% of patients.

- - - 

Is ibuprofen bad for my kidneys?

While NSAIDs rarely affect the liver, they have important adverse effects on the kidneys that you should know about. Here is the science behind the problem.

Ibuprofen and other NSAIDs block prostaglandins, natural body chemicals that normally dilate blood vessels leading to the kidneys. Blocking prostaglandins may lead to decreased blood flow to the kidneys, which means a lack of oxygen to keep the kidneys alive. That can cause acute kidney injury.

Acute kidney injury can occur with any NSAID, though naproxen seems to be a bigger culprit. In one study, folks who took NSAIDs had twice the risk of acute kidney injury within 30 days of starting to take the medications. People with existing kidney problems more often get in trouble.

The good news is these effects are reversible if you stop taking NSAIDs.

Remember, acute kidney injury from NSAIDs doesn’t cause any symptoms. if you are taking ibuprofen for long periods of time, it’s not a bad idea to have a check of your kidney function with a quick blood test. The test may show a rise in creatinine if your kidneys are being affected, usually seen within the first 3 to 7 days of NSAID therapy.

- - - 

Ibuprofen and other NSAIDs block prostaglandins, natural body chemicals that normally dilate blood vessels leading to the kidneys. Blocking prostaglandins may lead to decreased blood flow to the kidneys, which means a lack of oxygen to keep the kidneys alive. That can cause acute kidney injury.

Are NSAIDs Like Ibuprofen Bad for My Liver and Kidneys?

Biotin with L-Cysteine and Mineral Tablets



Biotin with L-Cysteine and Mineral Tablets
Pricing: 97.50 INR (March 2021)

Biotin is a vitamin. Foods such as eggs, milk, or bananas contain small amounts of biotin.

Biotin is used for biotin deficiency. It is also commonly used for hair loss, brittle nails, and other conditions, but there is no good scientific evidence to support these uses.

How does it work ?
Biotin is an important component of enzymes in the body that break down certain substances like fats, carbohydrates, and others.

There isn't a good laboratory test for detecting low biotin levels, so this condition is usually identified by its symptoms, which include thinning of the hair (frequently with loss of hair color) and red scaly rash around the eyes, nose, and mouth. Other symptoms include depression, tiredness, hallucinations, and tingling of the arms and legs. There is some evidence that diabetes could cause low biotin levels.

Biotin

- - - 

L-Cysteine:

Potent anti-oxidant protection to the hair follicle, facilitate longer hair growth.

L-cysteine is a semi-essential amino acid found naturally in the human body. Abundant in protein-rich foods, L-cysteine is also sold as a dietary supplement (sometimes just called cysteine). Along with the amino acids glutamine and glycine, cysteine is a building block of the powerful antioxidant glutathione. The body can make cysteine from the amino acids methionine and serine, but if these are in short supply, supplementing with L-cysteine can fill the gaps.

Among the uses promoted for L-cysteine are the easing of flu symptoms, the treatment of certain inflammatory diseases, and the management of diabetes.

In alternative medicine, L-cysteine is used as a natural treatment for:
1. Angina
2. Cardiovascular disease
3. Chronic bronchitis
4. Diabetes
5. Flu
6. Inflammation
7. Inflammatory bowel disease
8. Osteoarthritis

1: 1mg
2: verywellhealth.com

Volflam Plus (Diclofenac Sodium and Paracetamol)



Volflam Plus
Pricing: 25 INR (March 2021)

Uses

Diclofenac+Paracetamol is used for pain relief. 

It relieves pain in conditions like:

1. headache
2. mild migraine
3. muscle pain
4. dental pain 
5. rheumatoid arthritis
6. ankylosing spondylitis
7. osteoarthritis, or 
8. painful menses

Common Side Effects
Side Effects of Volflam Plus are: 
1. Nausea
2. Vomiting
3. Stomach pain/epigastric pain
4. Heartburn
5. Diarrhea 
6. Loss of appetite

Mechanism of action
These medicines work by blocking the action of chemical messengers responsible for:
1. pain
2. fever and 
3. inflammation (redness and swelling)

Q: Can the use of Volflam Plus 50 mg/325 mg Tablet cause damage to kidneys?
Ans:
Yes, the long-term use of Volflam Plus 50 mg/325 mg Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protect them from damage. Use of painkillers lowers the levels of prostaglandins in the body leading to kidney damage on long-term use. Use of painkillers is not recommended in patients with underlying kidney disease.

Q: Are there any specific contraindications associated with the use of Volflam Plus 50 mg/325 mg Tablet?
Ans:
The use of Volflam Plus 50 mg/325 mg Tablet is considered to be harmful in patients with known allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or in patients with active, recurrent stomach ulcer/bleeding. It should also be avoided in patients with the history of heart failure, high blood pressure, and liver or kidney disease.

[ Ref ]

Other notes
1. Related to 'Ankylosing Spondylitis':
HLA-B27 is a blood test to look for a protein that is found on the surface of white blood cells. The protein is called human leukocyte antigen B27 (HLA-B27). Human leukocyte antigens (HLAs) are proteins that help the body's immune system tell the difference between its own cells and foreign, harmful substances.

2. Paracetamol, also known as acetaminophen, is widely used as an analgesic and antipyretic drug. An acute paracetamol overdose can lead to potentially lethal liver and kidney failure in humans and experimental animals and in severe cases to death.

Paracetamol-Induced Renal Tubular Injury: A Role for ER Stress

March 02, 2008



Index of Journals
Sunday, 2 March 2008
Though I had nothing so special today but it wasn't boring and messy too! :) I woke up at 9:30 AM. Sorry. Sorry. 8:45 AM somthing like that... And then same schedule with all the time saved out for studies...
Went like this till the evening but at 4:30 PM badi buaji (Kumkum) and Shruti came her to bless Prashant and Anu and to wish them 'Good luck'.

Hardik called me twice to play but I didn't go because I had to study and complete my course. I went to see those girls playing basketball near B3 block. Sonal (I think) have got a new hair cut. I ignored her. Or maybe it was too dark for me to see her, to observe her face and tell you how she looked. 
I had thought of catching up with Dimpi for a while but she left with three of them. Disappointed. After that played basketball for a little while and then back home. 
It was so hot in the house, man! I was not feeling well but I adjusted somehow. 
I like to engage in idle talk with Anu and waste time, it is so fun. The way she imitate Sonal is so funny... The face expressions, the eyebrows and eyeball movements. I like it ;)

Manju buaji came at night, same reason. To wish Anu and Prashant good luck. Nothing about me. I would sleep around 12 PM and would wake up at 4 AM tomorrow. No compromise this time.

See you. Bye. Zzzz...

Ashish Jain
!MPoSS!BlE

Saturday, April 10, 2021

March 1, 2008



Index of Journals
Never seen a day as boring as this one...
I slept at 2:10 AM last night but still I managed to wake up at 8:00 for some moments... that is because actually I had thought of waking up at 7:00 and going to the temple for the same 'reason' but it was 8:00 so I again lost into the dreams. 
9:30: Woke up... brushed teeth... had breakfast... and then went for a bath. 
Washed hair with shampoo and had warm water bath after a month.
When I came out, I again went to bed with the book... and slept. It was 2:00 when I again woke up.... studies, studies, studies... Dimpi was looking great today. No comparison.
6:20 PM: When I was just planning to go out for a while, she was here in aunt's room and I went there to see her.
Nobody came to play today. So bad. Studied again on coming back home.
One more thing: when I had slept around 2:00 PM, the gum I was chewing was still in my mouth, felt odd but now I will get accustomed to it. 

In the evening today, there was no wind on the terrace so I got bored there and came down. 
When Anu complained to uncle about the fan, he also asked me to turn it off. What a messy day!

It should be over by 1'o clock by now, what else can I expect? Good night! See you! God bless me.

Tuesday, April 6, 2021

Hair fall and Folliserum FAQs



Q1: What is the hair growth cycle?

A1: Hair on the scalp grows about 0.3 to 0.4 mm/day or about 6 inches per year. At any given time, a random number of hair will be in one of three stages of growth and shedding.

Anagen: The active phase of the hair

Catagen: The transitional phase of hair

Talogen: The resting phase of hair

Q2: How much hair loss per day is considered normal?

A2: Almost everybody loses hair every day. It is normal if you lose about 50-100 hair per day.

Q3: Why am I experiencing hair loss?

A3: You may be losing hair due to many causes. Important causes that can lead to hair loss or hair thinning include:

1. Family history of baldness

2. Nutritional deficiencies like less protein and iron intake, excessive intake of vitamin A.

3. Physical or emotional stress.

4. Infections and hormonal disorders.

5. Childbirth, menstrual cycle and menopause.

6. Improper hair care such as excessive use of chemicals and blowers, etc.

Q4: Which areas of the head are most commonly affected?

A4: In men, baldness usually affects the hair line and crown area.

In women, initially there is thinning of the hair on the top of head which can lead to baldness.

Q5: How long can hair loss last?

A5: Duration of hair loss mainly depends on its cause. If you experience hair loss due to some stressful event or illness, then your hair may re-grow after few months. If you are expreriencing male pattern baldness, then it may continue for rest of your life. Hair loss due to any nutritional deficiency can last until you correct the diet and / or provided with appropriate nutritional supplement for such hair loss.

Q6: Is there any relation between my diet and hair loss?

A6: Yes, there is a link between diet and hair loss. A balanced diet is necessary for a healthy scalp and hair.

Proteins:
If you protein intake is less, it can also lead to hair loss. Therefore, eating protein-rich diet including nuts, seeds, beans, egg, fish, etc can help to stop your hair loss.

Vitamins:
A proper balance of vitamin A, B complex, C and E is essential for nourishment of hair follicle. Defeciency of these constituents may stop hair growth or make the hair brittle.

Iron:
Insufficient iron intake can also be a reason for your hair loss. Consuming iron-fortified cereals, soybeans, pumpkin seeds, white beans, lentils, and spinach may help you prevent hair loss.

Eating habits and disorder:
Crash diet, eating disorders like not having sufficient diet may lead to hair loss.

Q7: How is hair-loss treated?

A7: Treatment for hair loss is usually based on the cause of hair loss. Your doctor will identify the cause and treat your hair loss accordingly. In addition your doctor may prescibe you with nutritional supplements for the nourishment of hair which may play a role in hair loss treatment.

Q8: How should I take care of my hair?

A8: It is important to see your doctor if you observe excessive hair loss. Follow your doctor's advice and take your medications regularly. For good care of your hair and to reduce hair loss, it is essential to consider the following do's and don'ts.

Do's: 
1. Have a wholesome and balanced diet.

2. Use a good shampoo and conditioner regularly to reduce damage to your hair.

3. Consult a dermatologist to help you identify the cause of your hair loss and ways to prevent or treat it.

Don'ts:

1. Use of dyes and other chemical treatments like bleaching and perming.
Perms work by using chemicals to change hair texture, either creating waves or curls. Traditionally, a stylist will wrap hair in rods before putting perm lotion on to set the curl. After letting the lotion sit, stylists rinse it out, dry hair as much as possible, and use a neutralizer to halt the perming process.

2. Tight hair styles or elastic hair bands.

3. Brush or comb when the hair is wet.

4. Excessive scalp massage or brushing.


Q9: What is Folliserum?

A9: Folliserum is a novel hair growth serum used in the management of hair loss made of 5 active infredients. Folliserum is beneficial in the management of shedding of hair (Talogen Effluvium) as well as excessive thinning of hair or pattern hair loss (Androgenetic Alopecia). It is a cosmeticaly elegant and 'alcohol-free' formulation.

Q10: When do I see visible results?

A10: Visible results of treatment for hair loss depend on the cause, severity of hair loss, and also vary from person to person. It is very important to understand that under normal circumstances also, hair grows to about 1 cm in one month. Hence, you need to be patient, follow the doctor's advice and take medicines regularly as prescribed. It may take minimum of 3-6 months to see visible result. Some people tend to discontinue the treatment as they do not see the results spontaneously. Compliance plays a vital role in the treatment of hair loss.

Q11: What are the benefits of Folliserum?

A11: Folliserum is made up of 5 active ingredients namely Procapil, Adenosine, Niacinamide, Cococin and Melatonin. Adenosine increases blood supply to hair follicles by promoting dilation of blood vessels. Cococin has proteins, amino acids, sugars, vitamins and minerals that promote cell proliferation. Niacinamide reduces scalp inflammation while Procapil improves hair anchoring.

Q12: For how long should I use Folliserum?

A12: Folliserum is recommended to be used 1 ml twice a day for minimum of 3 months or as directed by physician.

Q13: Directions of use:

A13: Apply once or twice as recommended:

1. Take sufficient quantity of Folliserum on your palm.

2. Part hair and apply Folliserum on affected areas of the scalp.

3. Gently massage to rub in.

Q14: Precautions:

A14: Do not use on skin that is red, painful, scraped, irritated, cut or infected. Wash hands thoroughly after applicatioin. Avoid getting the product in your eyes. Rinse your eyes with large amounts of cool water if occurs.
Tags: Medicine,

Wednesday, March 31, 2021

Journal (Misbehavior By Tenors in Panchkula (Part 1))



20210331 My experience with tenors in my stay in Chandigarh / Panchkula has been pretty bad. I would go about them in points like this: I had moved from Manimajra to Panchkula in February 2019 in (let's say) Address XAbhishek Sindhwani's residence (1224, Sector 7, Panchkula). It was okay for few days in the beginning as the room had bed and almirah. The problems arose later that I should have anticipated while coming in. 1. There was no water tap. You have to either get the water from the market or drink the ground water. 2. The room had no curtains so you had no privacy as anyone from outside the room could view everything inside. 3. One of the windows (oppsite to the restroom door) had no metallic grill and anyone could break into the room by knocking down the glass pane. 4. The restroom would have two entrances from two separate rooms. The other room had space for two people, which means three people would be sharing the restroom. Note that the restroom was also the bathroom. 5. If the other tenants play loud music at the times such as mid night or hours past mid night, there was still little intervention or help from the tenor. I had to leave the place afer the tenors did not fix the curtains and privacy problem after repeated requests made for a period of about two months.
My experience with tenors in my stay in Chandigarh / Panchkula has been pretty bad. I would go about them in points like this:

I had moved from Manimajra to Panchkula in February 2019 in (let's say) Address XAbhishek Sindhwani's residence (1224, Sector 7, Panchkula). It was okay for few days in the beginning as the room had bed and almirah. The problems arose later that I should have anticipated while coming in.

1. There was no water tap. You have to either get the water from the market or drink the ground water.
    
2. The room had no curtains so you had no privacy as anyone from outside the room could view everything inside.

3. One of the windows (opposite to the restroom door) had no metallic grill and anyone could break into the room by knocking down the glass pane.

4. The restroom would have two entrances from two separate rooms. The other room had space for two people, which means three people would be sharing the restroom. Note that the restroom was also the bathroom.

5. If the other tenants play loud music at the times such as mid night or hours past mid night, there was still little intervention or help from the tenor.

I had to leave the place after the tenors did not fix the curtains and privacy problem after repeated requests made for a period of about two months.

Journal (Interactions with police)



Panchkula, April 2020:

Lockdown had been slightly relaxed and I was out to have parantha at Bachu Ram's shop. There I had been without mask and a cop car (a white Maruti Suzuki Dzire) went towards Divya Yog mandir while patrolling. I did not know what it was all about. After I finished eating, I paid for the food and started to walk back to home. Just as I was at the left turn to my street for my unguarded society (I don't know what else to call it), police car came from the front and stopped next to me. There were two police men in it at the front seats. Now, they ask me for Rs 500 fine for not wearing mask. I told them I did not have the money. They now asked me to get it their car and that they would drop me at my residence and collect the fine. Or I can come with them to the police station. Now, my house from this point was roughly 100 steps away but I was outside the gate (of society) and so had to pay the fine.

From that day onwards, I did not forget to go out without a mask.

Panchkula, February 7, 2021: 

Time was 9 PM and a tomato seller screamed at the top of his lungs for 40 to 50 minutes before I had to call the emergency number of 100 and ask the 'Constable' about what help I can get. He told me that it would be hard for a police personnel to keep vegetable vendors away from your house at all times. These people are given licences by the MC to sell those vegetables. If you face too much difficulty or trouble, you can always reach out to us. If you want I can send someone to come to your place even now and see if there is an issue.

Tuesday, March 30, 2021

Journal (Letter to my future wife)



I do not know who you are today. I do not know if you would be how I wish you to be. Let me still take up this opportunity to talk to you through this letter. 

English has been a major influence in my life. It has helped me to express myself, it has helped me in understanding the world through books, it has helped me to be able to talk to you in that first meeting. 

Today I cannot imagine myself without this language.

When I think of you, when I think of our kids, I see myself talking to my family in this language.

Also, I wish that you could focus on your career enough to support yourself and the kids shall I not be there for you. 

I do not wish to take responsibility for your happiness. I do not wish to take the responsibility for your well-being. I do not wish to take the responsibility to give you the things that you wish to have. And I say all of this while knowing that my happiness would be in seeing you happy. I will be healthier on seeing you fit and fine. I too want that you get everything that you deserve, everything that you yearn for.

I want you to be independent, I want to be independent.

Death and divorce are as much real as you and me. I could have painted a rosy picture in this writing but I chose not to. I believe in being prepared than being sorry.
Tags: Journal
Addendum: Written for Manvi

Issues in RASA CLI installation in Conda Env using YML file (and workarounds) (less logs)



We do not have "rasa" available in "conda-forge" channel:

(erasa4) CMD>conda install rasa -c conda-forge
Collecting package metadata (current_repodata.json): done
Solving environment: failed with initial frozen solve. Retrying with flexible solve.
Collecting package metadata (repodata.json): done
Solving environment: failed with initial frozen solve. Retrying with flexible solve.

PackagesNotFoundError: The following packages are not available from current channels:

  - rasa

Current channels:

  - https://conda.anaconda.org/conda-forge/win-64
  - https://conda.anaconda.org/conda-forge/noarch
  - https://repo.anaconda.com/pkgs/main/win-64
  - https://repo.anaconda.com/pkgs/main/noarch
  - https://repo.anaconda.com/pkgs/r/win-64
  - https://repo.anaconda.com/pkgs/r/noarch
  - https://repo.anaconda.com/pkgs/msys2/win-64
  - https://repo.anaconda.com/pkgs/msys2/noarch

To search for alternate channels that may provide the conda package you're
looking for, navigate to

    https://anaconda.org

and use the search bar at the top of the page.

-- -- -- -- --

ERRONEOUS CODE in FILE "env.yml"

name: erasa5
channels:
- conda-forge
dependencies:
- spacy
- python=3.8
- pip
- pip:
  - rasa
  - rasa-core

ERROR:

/ Pip subprocess error:
WARNING: Retrying (Retry(total=4, connect=None, read=None, redirect=None, status=None)) after connection broken by 'ProtocolError('Connection aborted.', ConnectionResetError(10054, 'An existing connection was forcibly closed by the remote host', None, 10054, None))': /simple/joblib/
ERROR: Could not install packages due to an OSError: [WinError 5] Access is denied: 'e:\\anaconda3\\envs\\erasa5\\scripts\\tqdm.exe'
Consider using the `--user` option or check the permissions.

failed

CondaEnvException: Pip failed

Complete Logs

(base) CMD>conda env create -f env.yml

Collecting package metadata (repodata.json): done
Solving environment: done
Preparing transaction: done
Verifying transaction: done
Executing transaction: done
Installing pip dependencies: / Ran pip subprocess with arguments:
['e:\\Anaconda3\\envs\\erasa5\\python.exe', '-m', 'pip', 'install', '-U', '-r', 'C:\\Users\\ashish\\Desktop\\condaenv.170xtvti.requirements.txt']
Pip subprocess output:
...
Installing collected packages: sniffio, ..., rasa-core, rasa
  Attempting uninstall: attrs
    Found existing installation: attrs 20.3.0
    Uninstalling attrs-20.3.0:
      Successfully uninstalled attrs-20.3.0
  Attempting uninstall: multidict
    Found existing installation: multidict 5.1.0
    Uninstalling multidict-5.1.0:
      Successfully uninstalled multidict-5.1.0
  Attempting uninstall: pytz
    Found existing installation: pytz 2021.1
    Uninstalling pytz-2021.1:
      Successfully uninstalled pytz-2021.1
  Attempting uninstall: numpy
    Found existing installation: numpy 1.20.0
    Uninstalling numpy-1.20.0:
      Successfully uninstalled numpy-1.20.0
  Attempting uninstall: tqdm
    Found existing installation: tqdm 4.56.0
    Uninstalling tqdm-4.56.0:

Pip subprocess error:
ERROR: Could not install packages due to an OSError: [WinError 5] Access is denied: 'e:\\anaconda3\\envs\\erasa5\\scripts\\tqdm.exe'
Consider using the `--user` option or check the permissions.

failed

CondaEnvException: Pip failed

(base) CMD>

-- -- -- -- -- 

We have a separate environment where we installed 'RASA_CORE' and 'RASA_NLU' separately, and here also we see that 'RASA' PYPI package (for RASA CLI) is failing to install.

ENV.YML for erasa4:

name: erasa4
channels:
- conda-forge
dependencies:
- spacy
- python=3.8
- pip
- pip:
  - rasa-core

(base) CMD>conda activate erasa4

Issues:
(erasa4) CMD>pip show rasa_core
Name: rasa-core
Version: 0.8.6
Summary: Machine learning based dialogue engine for conversational software.
Home-page: https://rasa.ai
Author: Rasa Technologies GmbH
Author-email: hi@rasa.ai
License: UNKNOWN
Location: e:\anaconda3\envs\erasa4\lib\site-packages
Requires: pandoc, ..., tqdm
Required-by:

(erasa4) CMD>pip show rasa_nlu
Name: rasa-nlu
Version: 0.11.5
Summary: Rasa NLU a natural language parser for bots
Home-page: https://rasa.com
Author: Alan Nichol
Author-email: alan@rasa.ai
License: UNKNOWN
Location: e:\anaconda3\envs\erasa4\lib\site-packages
Requires: future, numpy, simplejson, jsonschema, requests, cloudpickle, matplotlib, pathlib, klein, boto3, gevent, six, typing, tqdm
Required-by: rasa-core

(erasa4) CMD>pip show rasa
WARNING: Package(s) not found: rasa

-- -- -- -- -- 

ERROR

(erasa4) CMD>rasa
'rasa' is not recognized as an internal or external command, operable program or batch file.

(erasa4) CMD>rasa init
'rasa' is not recognized as an internal or external command, operable program or batch file.

RASA fails to install for all users.

(erasa4) CMD>pip3 install rasa

Collecting rasa
  Using cached rasa-2.2.9-py3-none-any.whl (689 kB)
...
Installing collected packages: sniffio, ..., rasa
  Attempting uninstall: multidict
    Found existing installation: multidict 5.1.0
    Uninstalling multidict-5.1.0:
      Successfully uninstalled multidict-5.1.0
  Attempting uninstall: yarl
    Found existing installation: yarl 1.6.3
    Uninstalling yarl-1.6.3:
      Successfully uninstalled yarl-1.6.3
  Attempting uninstall: numpy
    Found existing installation: numpy 1.19.5
    Uninstalling numpy-1.19.5:
      Successfully uninstalled numpy-1.19.5
  Attempting uninstall: attrs
    Found existing installation: attrs 20.3.0
    Uninstalling attrs-20.3.0:
      Successfully uninstalled attrs-20.3.0
  Attempting uninstall: absl-py
    Found existing installation: absl-py 0.11.0
    Uninstalling absl-py-0.11.0:
      Successfully uninstalled absl-py-0.11.0
  Attempting uninstall: tqdm
    Found existing installation: tqdm 4.56.0
    Uninstalling tqdm-4.56.0:
ERROR: Could not install packages due to an OSError: [WinError 5] Access is denied: 'e:\\anaconda3\\envs\\erasa4\\scripts\\tqdm.exe'
Consider using the `--user` option or check the permissions.

(erasa4) CMD>

-- -- -- -- --

To install RASA CLI (and overcome the installation issue in "erasa4" environment) we have to open the terminal and run the "pip3 install rasa --user" command there:

(erasa4) CMD>pip3 install rasa --user
Collecting rasa
  Using cached rasa-2.2.9-py3-none-any.whl (689 kB)
...
Installing collected packages: tqdm, ..., rasa
  WARNING: The script tqdm.exe is installed in 'C:\Users\ashish\AppData\Roaming\Python\Python38\Scripts' which is not on PATH.
  Consider adding this directory to PATH or, if you prefer to suppress this warning, use --no-warn-script-location.
  WARNING: The script tabulate.exe is installed in 'C:\Users\ashish\AppData\Roaming\Python\Python38\Scripts' which is not on PATH.
  Consider adding this directory to PATH or, if you prefer to suppress this warning, use --no-warn-script-location.
  WARNING: The script coloredlogs.exe is installed in 'C:\Users\ashish\AppData\Roaming\Python\Python38\Scripts' which is not on PATH.
  Consider adding this directory to PATH or, if you prefer to suppress this warning, use --no-warn-script-location.
  WARNING: The scripts make_image_classifier.exe and make_nearest_neighbour_index.exe are installed in 'C:\Users\ashish\AppData\Roaming\Python\Python38\Scripts' which is not on PATH.
  Consider adding this directory to PATH or, if you prefer to suppress this warning, use --no-warn-script-location.
  WARNING: The scripts estimator_ckpt_converter.exe, saved_model_cli.exe, tensorboard.exe, tf_upgrade_v2.exe, tflite_convert.exe, toco.exe and toco_from_protos.exe are installed in 'C:\Users\ashish\AppData\Roaming\Python\Python38\Scripts' which is not on PATH.
  Consider adding this directory to PATH or, if you prefer to suppress this warning, use --no-warn-script-location.
  WARNING: The script pykwalify.exe is installed in 'C:\Users\ashish\AppData\Roaming\Python\Python38\Scripts' which is not on PATH.
  Consider adding this directory to PATH or, if you prefer to suppress this warning, use --no-warn-script-location.
  WARNING: The script rasa.exe is installed in 'C:\Users\ashish\AppData\Roaming\Python\Python38\Scripts' which is not on PATH.
  Consider adding this directory to PATH or, if you prefer to suppress this warning, use --no-warn-script-location.
ERROR: pip's dependency resolver does not currently take into account all the packages that are installed. This behaviour is the source of the following dependency conflicts.
rasa-core 0.8.6 requires fbmessenger<5.0.0, but you have fbmessenger 6.0.0 which is incompatible.
rasa-core 0.8.6 requires pykwalify<=1.6.0, but you have pykwalify 1.7.0 which is incompatible.
Successfully installed PyJWT-2.0.1 SQLAlchemy-1.3.23 aio-pika-6.7.1 aiohttp-3.6.3 ... webexteamssdk-1.6

(erasa4) CMD> 

(erasa4) CMD>pip show rasa
Name: rasa
Version: 2.2.9
Summary: Open source machine learning framework to automate text- and voice-based conversations: NLU, dialogue management, connect to Slack, Facebook, and more - Create chatbots and voice assistants
Home-page: https://rasa.com
Author: Rasa Technologies GmbH
Author-email: hi@rasa.com
License: Apache-2.0
Location: c:\users\ashish\appdata\roaming\python\python38\site-packages
Requires: pykwalify, ..., tensorflow-probability
Required-by: 

-- -- -- -- --

(erasa4) CMD>rasa
2021-02-03 14:50:58.305729: W tensorflow/stream_executor/platform/default/dso_loader.cc:59] Could not load dynamic library 'cudart64_101.dll'; dlerror: cudart64_101.dll not found
2021-02-03 14:50:58.313121: I tensorflow/stream_executor/cuda/cudart_stub.cc:29] Ignore above cudart dlerror if you do not have a GPU set up on your machine.
usage: rasa [-h] [--version] {init,run,shell,train,interactive,telemetry,test,visualize,data,export,x} ...

Rasa command line interface. Rasa allows you to build your own conversational assistants 🤖. The 'rasa' command allows you to easily run most common commands like creating a new bot, training or evaluating models.

positional arguments:
  {init,run,shell,train,interactive,telemetry,test,visualize,data,export,x}
                        Rasa commands
    init                Creates a new project, with example training data, actions, and config files.
    run                 Starts a Rasa server with your trained model.
    shell               Loads your trained model and lets you talk to your assistant on the command line.
    train               Trains a Rasa model using your NLU data and stories.
    interactive         Starts an interactive learning session to create new training data for a Rasa model by chatting.
    telemetry           Configuration of Rasa Open Source telemetry reporting.
    test                Tests Rasa models using your test NLU data and stories.
    visualize           Visualize stories.
    data                Utils for the Rasa training files.
    export              Export conversations using an event broker.

optional arguments:
  -h, --help            show this help message and exit
  --version             Print installed Rasa version

(erasa4) CMD>

-- -- -- -- --

ALSO, WE SHARE BELOW THE LOGS WHILE DOING INSTALLATION FROM TERMINAL WITHOUT USING YML FILE

(base) CMD>conda create -n temp_rasa python=3.8

Collecting package metadata (current_repodata.json): done
Solving environment: done

## Package Plan ##

  environment location: e:\Anaconda3\envs\temp_rasa

  added / updated specs:
    - python=3.8

The following packages will be downloaded:

    package                    |            build
    ---------------------------|-----------------
    certifi-2020.12.5          |   py38haa95532_0         141 KB
    pip-20.3.3                 |   py38haa95532_0         1.8 MB
    setuptools-52.0.0          |   py38haa95532_0         726 KB
    ------------------------------------------------------------
                                            Total:         2.6 MB

The following NEW packages will be INSTALLED:

  ca-certificates    pkgs/main/win-64::ca-certificates-2021.1.19-haa95532_0
  certifi            pkgs/main/win-64::certifi-2020.12.5-py38haa95532_0
  openssl            pkgs/main/win-64::openssl-1.1.1i-h2bbff1b_0
  pip                pkgs/main/win-64::pip-20.3.3-py38haa95532_0
  python             pkgs/main/win-64::python-3.8.5-h5fd99cc_1
  setuptools         pkgs/main/win-64::setuptools-52.0.0-py38haa95532_0
  sqlite             pkgs/main/win-64::sqlite-3.33.0-h2a8f88b_0
  vc                 pkgs/main/win-64::vc-14.2-h21ff451_1
  vs2015_runtime     pkgs/main/win-64::vs2015_runtime-14.27.29016-h5e58377_2
  wheel              pkgs/main/noarch::wheel-0.36.2-pyhd3eb1b0_0
  wincertstore       pkgs/main/win-64::wincertstore-0.2-py38_0
  zlib               pkgs/main/win-64::zlib-1.2.11-h62dcd97_4

Proceed ([y]/n)? y

Downloading and Extracting Packages
certifi-2020.12.5    | 141 KB    | ### | 100%
setuptools-52.0.0    | 726 KB    | ### | 100%
pip-20.3.3           | 1.8 MB    | ### | 100%
Preparing transaction: done
Verifying transaction: done
Executing transaction: done
#
# To activate this environment, use
#
#     $ conda activate temp_rasa
#
# To deactivate an active environment, use
#
#     $ conda deactivate 

(temp_rasa) CMD>pip install rasa
Requirement already satisfied: rasa in c:\users\ashish\appdata\roaming\python\python38\site-packages (2.2.9)
...
Installing collected packages: sniffio, ..., apscheduler
Successfully installed PyYAML-5.4.1 absl-py-0.10.0 aiofiles-0.6.0 ... yarl-1.5.1

(temp_rasa) CMD>

(temp_rasa) CMD>pip show rasa
Name: rasa
Version: 2.2.9
Summary: Open source machine learning framework to automate text- and voice-based conversations: NLU, dialogue management, connect to Slack, Facebook, and more - Create chatbots and voice assistants
Home-page: https://rasa.com
Author: Rasa Technologies GmbH
Author-email: hi@rasa.com
License: Apache-2.0
Location: c:\users\ashish\appdata\roaming\python\python38\site-packages
Requires: sanic-cors, ..., colorhash
Required-by:

(temp_rasa) CMD>rasa

2021-02-03 15:19:23.023468: W tensorflow/stream_executor/platform/default/dso_loader.cc:59] Could not load dynamic library 'cudart64_101.dll'; dlerror: cudart64_101.dll not found
2021-02-03 15:19:23.030147: I tensorflow/stream_executor/cuda/cudart_stub.cc:29] Ignore above cudart dlerror if you do not have a GPU set up on your machine.
usage: rasa [-h] [--version] {init,run,shell,train,interactive,telemetry,test,visualize,data,export,x} ...

Rasa command line interface. Rasa allows you to build your own conversational assistants 🤖. The 'rasa' command allows you to easily run most common commands like creating a new bot, training or evaluating models.

positional arguments:
  {init,run,shell,train,interactive,telemetry,test,visualize,data,export,x}
                        Rasa commands
    init                Creates a new project, with example training data, actions, and config files.
    run                 Starts a Rasa server with your trained model.
    shell               Loads your trained model and lets you talk to your assistant on the command line.
    train               Trains a Rasa model using your NLU data and stories.
    interactive         Starts an interactive learning session to create new training data for a Rasa model by chatting.
    telemetry           Configuration of Rasa Open Source telemetry reporting.
    test                Tests Rasa models using your test NLU data and stories.
    visualize           Visualize stories.
    data                Utils for the Rasa training files.
    export              Export conversations using an event broker.

optional arguments:
  -h, --help            show this help message and exit
  --version             Print installed Rasa version

(temp_rasa) CMD>

Title: Issues in RASA CLI installation in Conda Env using YML file (and workarounds) (less logs)

Tags: Technology,Python,

Original URL: https://survival8.blogspot.com/2021/02/issues-in-rasa-installation-in-conda.html
Original date: Wednesday, February 3, 2021