Volflam Plus (Diclofenac Sodium and Paracetamol)

Volflam Plus
Pricing: 25 INR (March 2021)

Uses

Diclofenac+Paracetamol is used for pain relief. 

It relieves pain in conditions like:

1. headache
2. mild migraine
3. muscle pain
4. dental pain 
5. rheumatoid arthritis
6. ankylosing spondylitis
7. osteoarthritis, or 
8. painful menses

Common Side Effects
Side Effects of Volflam Plus are: 
1. Nausea
2. Vomiting
3. Stomach pain/epigastric pain
4. Heartburn
5. Diarrhea 
6. Loss of appetite

Mechanism of action
These medicines work by blocking the action of chemical messengers responsible for:
1. pain
2. fever and 
3. inflammation (redness and swelling)

Q: Can the use of Volflam Plus 50 mg/325 mg Tablet cause damage to kidneys?
Ans:
Yes, the long-term use of Volflam Plus 50 mg/325 mg Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protect them from damage. Use of painkillers lowers the levels of prostaglandins in the body leading to kidney damage on long-term use. Use of painkillers is not recommended in patients with underlying kidney disease.

Q: Are there any specific contraindications associated with the use of Volflam Plus 50 mg/325 mg Tablet?
Ans:
The use of Volflam Plus 50 mg/325 mg Tablet is considered to be harmful in patients with known allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or in patients with active, recurrent stomach ulcer/bleeding. It should also be avoided in patients with the history of heart failure, high blood pressure, and liver or kidney disease.

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Other notes
1. Related to 'Ankylosing Spondylitis':
HLA-B27 is a blood test to look for a protein that is found on the surface of white blood cells. The protein is called human leukocyte antigen B27 (HLA-B27). Human leukocyte antigens (HLAs) are proteins that help the body's immune system tell the difference between its own cells and foreign, harmful substances.

2. Paracetamol, also known as acetaminophen, is widely used as an analgesic and antipyretic drug. An acute paracetamol overdose can lead to potentially lethal liver and kidney failure in humans and experimental animals and in severe cases to death.

Paracetamol-Induced Renal Tubular Injury: A Role for ER Stress