Itraconazole

Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. It may be given by mouth or intravenously. Serious liver damage will occur if Itraconazole is taken in conjunction with alcohol.

Common side effects include nausea, diarrhea, abdominal pain, rash, and headache. Severe side effects may include liver problems, heart failure, Stevens–Johnson syndrome and allergic reactions including anaphylaxis. It is unclear if use during pregnancy or breastfeeding is safe. It is in the triazole family of medications. It stops fungal growth by affecting the cell membrane or affecting their metabolism.

Itraconazole was patented in 1978 and approved for medical use in the United States in 1992. It is on the World Health Organization's List of Essential Medicines.

Recent research works suggest itraconazole (ITZ) could also be used in the treatment of cancer by inhibiting the hedgehog pathway.
From: Wikipedia

Note: All of the above writing seems to be pertaining to the oral dose of Itraconazole and that would be capsules and not gel.

When we thought to start this post, we had "Itraconazole Gel" in the mind.

Itrostred Gel

Prescription Required
Manufacturer: Leeford Healthcare Ltd
SALT COMPOSITION: Itraconazole (1% w/w)

Pricing (Mar 2021): 75 INR for 15 Grams Tube

Other preservatives:

1. Methylparaben (0.1% w/w)
Methylparaben is an anti-fungal agent often used in a variety of cosmetics and personal-care products. It is also used as a food preservative and has the E number E218. [ Ref ]

2. Propyl Paraben (0.05% w/w)

Propylparaben is the benzoate ester that is the propyl ester of 4-hydroxybenzoic acid. Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. Also used as a food additive. It has a role as an antifungal agent and an antimicrobial agent. [ Ref ]

Description

Itrostred Gel belongs to a group of medicines called antifungals. It works by stopping the growth of fungus and is used to treat skin infections including infections of the fingernails and toenails. It kills fungi by destroying the fungal cell membrane.

Itrostred Gel is for external use only. You should use it in the dose and duration as advised by your doctor. The affected area should be clean and dry before application of the medicine. You must wash your hands thoroughly before and after applying this medicine. Skin infections will usually get better after 2 to 4 weeks. Do not use the medicine for longer than your doctor has told you to and let him or her know if your condition does not improve after 2 to 4 weeks of treatment.  If you have athlete’s foot, wash your socks or tights thoroughly and change your shoes daily if possible.

Side effects of Itrostred Gel

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Common side effects of Itrostred:

% Application site reactions (burning, irritation, itching and redness)

Ref: 1mg
Tags: Medicine