Tuesday, March 16, 2021

Domperidone



Domperidone is a medication used as an antiemetic, gastric prokinetic agent, and galactagogue.

Dosage

In April 2014 Co-ordination Group for Mutual Recognition and Decentralised Procedures – Human (CMDh) published official press-release suggesting to restrict the use of domperidone-containing medicines. It also approved earlier published suggestions by Pharmacovigilance Risk Assessment Committee (PRAC) to use domperidone only for curing nausea and vomiting and reduce maximum daily dosage to 10 mg.

Ref 1: Domperidone
Ref 2: Restricting Domperidone Use

Products in Market

1.
Vomistop Tablet
Manufacturer: Cipla Ltd
SALT COMPOSITION: Domperidone (10mg) [This is the proposed maximum dosage limit for this drug.]

Ref: Vomistop

2. 
Domstal 10mg Tablet
Manufacturer: Torrent Pharmaceuticals Ltd
SALT COMPOSITION: Domperidone (10mg)

Ref: Domstal

According to the above '1mg' reference:
Domstal 10mg Tablet is a prescription medicine used in the treatment of indigestion, nausea and vomiting. It blocks the substance on the brain that triggers nausea or vomiting and it also increases the movement of food in the stomach, thereby improves digestion.

From Wikipedia:
The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasing gastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin.
Also, it is a peripherally selective dopamine D2 receptor antagonist.

Note:

- Nausea is feeling an urge to vomit. It is often called "being sick to your stomach." 

- Vomiting or throwing-up is forcing the contents of the stomach up through the food pipe (esophagus) and out of the mouth.

There is some evidence that domperidone has antiemetic activity. It is recommended by the Canadian Headache Society for treatment of nausea associated with acute migraine. 

Ref: Canadian headache society guideline acute drug therapy for Migraine headache

Tags: Science,Medicine,

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