Propyphenazone

Introduction
Propyphenazone (known as isopropylantipyrine in Japan) is a derivative of phenazone with similar analgesic and antipyretic effects. Originally patented in 1931, propyphenazone is marketed as a combination formulation with paracetamol and caffeine for treatment of primary headache disorder.

Serious adverse events

Case reports have described acute inferior-wall myocardial infarctions characterized by low atrial rhythms[vague] (Kounis syndrome) secondary to propyphenazone use.

Excerpt from WHO comments

Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations.

Ref: wikipedia 

More Details

Therapeutic Classification : Analgesic (of a drug: acting to relieve pain) And Antipyretic (of a drug: used to prevent or reduce fever) Agent

Trade Names/Brand Names of Propyphenazone: Dart

Overview of Propyphenazone

• Propyphenazone is an analgesic and antipyretic, with some anti-inflammatory activity.
• It is used to reduce fever and pain in conditions like headache and toothache. 

What is the dosage of Propyphenazone?

• The recommended dose of the drug is 75 to 150 mg tablet orally.
• It is usually available as a combination with other drugs like caffeine and paracetamol.

How should Propyphenazone be taken?

• Propyphenazone should be taken up to a maximum of four times a day.

Ref: medindia.net

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