Do not go gentle into that good night Dylan Thomas - 1914-1953 Dylan Marlais Thomas, born October 27, 1914, in South Wales, was the archetypal Romantic poet of the popular American imagination Do not go gentle into that good night, Old age should burn and rave at close of day; Rage, rage against the dying of the light. Though wise men at their end know dark is right, Because their words had forked no lightning they Do not go gentle into that good night. Good men, the last wave by, crying how bright Their frail deeds might have danced in a green bay, Rage, rage against the dying of the light. Wild men who caught and sang the sun in flight, And learn, too late, they grieved it on its way, Do not go gentle into that good night. Grave men, near death, who see with blinding sight Blind eyes could blaze like meteors and be gay, Rage, rage against the dying of the light. And you, my father, there on the sad height, Curse, bless, me now with your fierce tears, I pray. Do not go gentle into that good night. Rage, rage against the dying of the light. "Do not go gentle into that good night" is a line referred too often in the 2014 movie "Interstellar". In the 2014 movie Interstellar, the poem is used repeatedly by Michael Caine's character Professor John Brand, as well as by several other supporting characters. In the same movie, leading actors Matthew McConaughey and Anne Hathaway are sent into hypersleep with the final words "Do not go gentle into that good night." In the deluxe edition of the film's soundtrack, actors John Lithgow, Ellen Burstyn, Casey Affleck, Jessica Chastain, Matthew McConaughey, and Mackenzie Foy recite the poem with a soft vocal accompaniment scored by Hans Zimmer, the composer of the film's soundtrack. Ref 1: wikipedia Ref 2: YouTube
Tuesday, May 4, 2021
Do not gentle into that good night (Dylan Thomas)
Monday, May 3, 2021
First time with 'Git LFS' (Git for Large Files)
Notice how our "git push" fails due to the presence of a file larger than 100MB:
(base) \gh\vid3>git push
Logon failed, use ctrl+c to cancel basic credential prompt.
Username for 'https://github.com': a@b.c
Password for 'https://a@b.c@github.com':
Enumerating objects: 5, done.
Counting objects: 100% (5/5), done.
Delta compression using up to 4 threads
Compressing objects: 100% (4/4), done.
error: RPC failed; curl 92 HTTP/2 stream 0 was not closed cleanly: Unknown error code (err 8)
Wfatal: the remote end hung up unexpectedly
Writing objects: 100% (4/4), 533.93 MiB | 8.86 MiB/s, done.
Total 4 (delta 0), reused 0 (delta 0), pack-reused 0
fatal: the remote end hung up unexpectedly
Everything up-to-date
To overcome this, we install: git-lfs-windows-v2.13.2.exe
And run the following commands:
(base) \gh\vid3>git lfs install
Updated git hooks.
Git LFS initialized.
(base) \gh\vid3>git lfs track "*.*"
Tracking "*.*"
Pattern *.* matches forbidden file .gitignore. If you would like to track .gitignore, modify .gitattributes manually.
(base) \gh\vid3> git lfs track "*.mp4"
Tracking "*.mp4"
(base) \gh\vid3>git add .gitattributes
Note: if we do not do "add & commit" again before "push" again, it results in error:
(base) \gh\vid3>git push
Enumerating objects: 5, done.
Counting objects: 100% (5/5), done.
Delta compression using up to 4 threads
Compressing objects: 100% (4/4), done.
error: RPC failed; curl 92 HTTP/2 stream 0 was not closed cleanly: Unknown error code (err 8)
Wfatal: the remote end hung up unexpectedly
Writing objects: 100% (4/4), 533.93 MiB | 8.37 MiB/s, done.
Total 4 (delta 0), reused 0 (delta 0), pack-reused 0
fatal: the remote end hung up unexpectedly
Everything up-to-date
After we rename files, add and commit them:
(base) \gh\vid3>git status
On branch main
Your branch is ahead of 'origin/main' by 1 commit.
(use "git push" to publish your local commits)
Changes to be committed:
(use "git restore --staged <file>..." to unstage)
new file: .gitattributes
Changes not staged for commit:
(use "git add/rm <file>..." to update what will be committed)
(use "git restore <file>..." to discard changes in working directory)
deleted: 20210420 174746.mp4
deleted: 20210420_174746.mp4
Untracked files:
(use "git add <file>..." to include in what will be committed)
20210420 174746 (27 MB).mp4
20210420 174746 (521 MB).mp4
If you have low network speed, your "git push" might fail like this:
(base) \gh\vid3>git push
LFS: Client error: https://github-cloud.s3.amazonaws.com/alambic/media/3...2/0f/65/0...f?actor_id=8...7&key_id=0&repo_id=3...1
error: failed to push some refs to 'https://github.com/ashishjainblogger/vid3.git'
(base) \gh\vid3>git push
Uploading LFS objects: 67% (2/3), 98 MB | 105 KB/s
Exiting because of "interrupt" signal.
Additional Note:
My Airtel 4G VoLTE Mobile Hotspot (May 2021) was giving an upload speed of roughly 100 to 200 KB/s.
If everything about the Git-LFS goes right
(base) C:\Users\Ashish Jain\OneDrive\Desktop\gh\vid3>git push
Uploading LFS objects: 67% (2/3), 91 MB | 107 KB/s
A successful attempt logs go like this:
(base) \gh\vid3>git push
Uploading LFS objects: 100% (1/1), 27 MB | 0 B/s, done.
Enumerating objects: 7, done.
Counting objects: 100% (7/7), done.
Delta compression using up to 4 threads
Compressing objects: 100% (5/5), done.
Writing objects: 100% (6/6), 713 bytes | 237.00 KiB/s, done.
Total 6 (delta 1), reused 0 (delta 0), pack-reused 0
remote: Resolving deltas: 100% (1/1), done.
To https://github.com/ashishjainblogger/vid3.git
2*a..e*7 main -> main
[ Ref ]
Wednesday, April 28, 2021
Hair fall treatment through nutraceuticals (Keraglo and Follihair)
Hair fall treatment is very expensive and it starts with nutraceuticals such as Keraglo and / or Follihair.
These supplements contain (for example) 'vitamins, minerals, amino acids, with isoflavones and grape seed extract' in Follihair.
Your doctor (dermatologist) might ask you to take one pill of one brand in the morning and one pill of another brand at night (total two in a day).
Now how much does it cost you?
Keraglo for men: 10 tablets (strip) for 200 INR (as of March 2021)
Follihair (by Abbott): 30 tablets (bottle) for 583 INR (as of March 2021)
If you take these pills for a month to begin with, that means you have to spend 1183 INR every month on a problem as trivial as hair fall that could also be genetic.
The thing to note here is that your dermatologist might not ask to get a full body test for essential vitamins and minerals, for large internal organs, for hormones, etc, but still prescribe the nutraceuticals to you.
The thing to note here is that even excess of vitamins in the body is dangerous and harmful for your body.
For example: Biotin is a water-soluble vitamin that's a part of the vitamin B family. It's also known as vitamin H. Your body needs biotin to help convert certain nutrients into energy. It also plays an important role in the health of your hair, skin, and nails.
Biotin supplements can cause problems if you ingest too much. Side effects can include skin rashes, digestive upset, problems with insulin release, and kidney problems.
Tuesday, April 27, 2021
YouTube Channel Description
YouTube channel description in 1000 characters This channel is for posting videos from places I have been to, places I go to, and from road routes I take on normal days. I would want to see improvement in the world around and this capturing of everyday world would allow me to see how world is changing on day-to-day basis. Yes, day to day. Another reason for capturing these videos is that they allow me to have a memoir of days I spend in a place. Capturing videos like this allows me (at times) to remember where a dentist center is, where a pharmacy is, where an Airtel or Vodafone mobile store is, where a food outlet is, etc. I like dogs very much. They are beautiful creatures. Dogs are another reason for me to capture videos. When I find a dog and I feel like playing with it, I do that and capture those moments as videos. Very often you would find dark areas even in cities like Delhi and Chandigarh and when I capture those areas when I am required to pass through them, I videotape the place for safety and security reasons. Some links: % My website % Facebook Profile % Twitter Profile % The YouTube Page A Legal Notice About Videos on YouTube Regardless of your location, you're legally required to comply with the Children's Online Privacy Protection Act (COPPA) and/or other laws. You're required to tell us whether your videos are 'Made for Kids'. Features like personalised ads and notifications won't be available on videos 'Made for Kids'. Videos that are set as 'Made for Kids' by you are more likely to be recommended alongside other children's videos. [ Learn More ] 1: 20210420 174746 [Link] Desc (max 5000 characters): This is on one evening (2021-Apr-20 5:47 PM) when I had to go out to get milk from the nearby Vita dairy booth in Chandigarh IT park. There I also found the puppies with I usually play with. You would see in the video that I bought two milk packets out which one was for the puppies. The point to note about these puppies is that they did not even finish the entire 500 mL milk I had poured for them in their bowl. 2: 20210425 170822 [ URL ] Mansa Devi Gateway and Crossing area in MDC5, Panchkula, Haryana. 3: 20210430 091455 [ URL ] The MDC6, Panchkula area is not yet properly developed. As of May 2021, you would find that every second block is under-construction and an awful lot of clutter, waster and noise pollution is present in this area. Going from MDC6 towards MDC5 Market (Panchkula). 4: 20210430 091552 (Size: 94MB) [ URL ] Going from MDC6 towards MDC5 Market (Panchkula). 5: 20210430 113944 [ URL ] MDC 5 Market, Panchkula, Haryana. A few seconds in the video show that streets are not as clean as we would expect in a western country (and India is not a western country).
Sunday, April 18, 2021
We Need 'Cost of Living Adjustment' Act (Case Study II in 2021)
The following data is of a senior woman living in North-West Delhi (at her self-owned residence) taken from Aug-2019 till Jun-2021. Her major expenses are like LPG cylineder costing about 815 INR at the time of this writing.
| Month | Expenses |
| Aug 2019 | 5218 |
| Sep 2019 | 5527 |
| Oct 2019 | 5127 |
| Nov 2019 | 4021 |
| Dec 2019 | 5120 |
| Jan 2020 | 5654 |
| Feb 2020 | 4937 |
| Mar 2020 | 3017 |
| Apr 2020 | 3690 |
| May 2020 | 4169 |
| Jun 2020 | 2814 |
| Jul 2020 | 3296 |
| Aug 2020 | 3620 |
| Sep 2020 | 5560 |
| Oct 2020 | 3205 |
| Nov 2020 | 3844 |
| Dec 2020 | 5673 |
| Jan 2021 | 3442 |
| Feb 2021 | 3295 |
| Mar 2021 | 6043 |
| Apr 2021 | 3676 |
| May 2021 | 3604 |
| Jun 2021 | 5205 |
Wednesday, April 14, 2021
Starting a new GitHub project from CLI
$ mkdir github_test
$ cd github_test
$ echo "Hello" > test.txt
$ ls
test.txt
$ git init
Initialized empty Git repository in /home/administrator/Desktop/github_test/.git/
$ git add -A
$ git status
On branch master
No commits yet
Changes to be committed:
(use "git rm --cached <file>..." to unstage)
new file: test.txt
$ git commit -m "1654"
[master (root-commit) f571b69] 1654
1 file changed, 1 insertion(+)
create mode 100644 test.txt
$ git status
On branch master
nothing to commit, working tree clean
$ ls
test.txt
$ ls -la
total 16
drwxrwxr-x 3 administrator administrator 4096 Apr 13 16:54 .
drwxr-xr-x 4 administrator administrator 4096 Apr 13 16:53 ..
drwxrwxr-x 8 administrator administrator 4096 Apr 13 16:54 .git
-rw-rw-r-- 1 administrator administrator 6 Apr 13 16:54 test.txt
$ ls -laR
.:
total 16
drwxrwxr-x 3 administrator administrator 4096 Apr 13 16:54 .
drwxr-xr-x 4 administrator administrator 4096 Apr 13 16:53 ..
drwxrwxr-x 8 administrator administrator 4096 Apr 13 16:54 .git
-rw-rw-r-- 1 administrator administrator 6 Apr 13 16:54 test.txt
./.git:
total 52
...
...
drwxrwxr-x 4 administrator administrator 4096 Apr 13 16:54 ..
$ git remote add origin https://github.com/${username}/test2.git
$ git branch
* master
$ git push origin master
Username for ...
Password for ...
remote: Invalid username or password.
fatal: Authentication failed for ....
= = = = = = = = =
Intructions from GitHub portal
Quick setup — if you’ve done this kind of thing before
or
https://github.com/${username}/test2.git
Get started by creating a new file or uploading an existing file. We recommend every repository include a README, LICENSE, and .gitignore.
…or create a new repository on the command line
echo "# test2" >> README.md
git init
git add README.md
git commit -m "first commit"
git branch -M main
git remote add origin https://github.com/${username}/test2.git
git push -u origin main
…or push an existing repository from the command line
git remote add origin https://github.com/${username}/test2.git
git branch -M main
git push -u origin main
…or import code from another repository
You can initialize this repository with code from a Subversion, Mercurial, or TFS project.
Word Meanings 2021-04-14
1.
aqua
/ˈakwə/
noun
noun: aqua
a light bluish-green colour; aquamarine.
"houses of yellow and aqua"
- - -
2.
in vivo
/ɪn ˈviːvəʊ/
Biology
adjective
adjective: in vivo
(of a process) performed or taking place in a living organism.
"in vivo studies in animals"
adverb
adverb: in vivo
in a living organism.
"fluid transport was measured in vivo"
- - -
3.
in vitro
/ɪn ˈviːtrəʊ/
Biology
adjective
adjective: in vitro; adjective: invitro
(of a process) performed or taking place in a test tube, culture dish, or elsewhere outside a living organism.
"in vitro fertilization"
adverb
adverb: in vitro
in a test tube, culture dish, or elsewhere outside a living organism.
"the parasites could not be grown in vitro"
Origin
- - -
4.
surfactant: a substance which tends to reduce the surface tension of a liquid in which it is dissolved.
solubilizer: an agent that increases the solubility of a substance.
emulsifier: An emulsifier is an additive which helps two liquids mix. For example, water and oil separate in a glass, but adding an emulsifier will help the liquids mix together. Some examples of emulsifiers are egg yolks and mustard.
emollient: Emollients are substances that soften and moisturize the skin and decrease itching and flaking.
- - -
5.
flavonoid
/ˈfleɪvənɔɪd/
nounChemistry
noun: flavonoid; plural noun: flavonoids
any of a large class of plant pigments having a structure based on or similar to that of flavone.
- - -
6.
Neutraceutical:
The term nutraceutical, originally coined by Stephen De Felice [42], is, in this context, intended as: (i) the phytocomplex for food or part of food of vegetal origin; and (ii) the pool of secondary metabolites for food or part of food of animal origin [43]. This novel concept’ definition has been proposed to better evaluate the standard term of the word nutraceutical, and to highlight the difference between nutraceuticals, food supplements, and the many other plant-food-derived compounds that claim health-promoting effects. Nutraceuticals must be administered in a proper pharmaceutical way to guarantee high bioavailability and efficacy, and used in areas that go “beyond the diet and before the drugs” [44]. Nutraceuticals form a growing and powerful toolbox that is triggering a revolution in the area of disease prevention and also in the treatment for some clinical situations, in particular for individuals who may not yet be eligible for conventional pharmaceutical therapy, e.g., with conditions linked to metabolic syndrome. It is therefore necessary to unequivocally determine the definition of nutraceuticals, and to have an internationally shared regulation framework. It would also be advisable to determine nutraceuticals’ safety, modes of action and efficacy with clinical data before naming a product as “nutraceutical”, a term that must be substantiated by safety, no side effects, and proven health beneficial properties.
Ref: Neutraceutical
By: US National Library of Medicine, and National Institutes of Health
- - -
7.
metabolite:
(meh-TA-boh-lite) A substance made or used when the body breaks down food, drugs or chemicals, or its own tissue (for example, fat or muscle tissue). This process, called metabolism, makes energy and the materials needed for growth, reproduction, and maintaining health.
- - -
8.
pharmacological
/ˌfɑːməkəˈlɒdʒɪk(ə)l/
adjective
adjective: pharmacological; adjective: pharmacologic
relating to the branch of medicine concerned with the uses, effects, and modes of action of drugs.
"pharmacological treatment for depression"
- - -
9.
renal
/ˈriːn(ə)l/
adjectivetechnical
adjective: renal
relating to the kidneys.
"renal failure"
- - -
10.
rennin
/ˈrɛnɪn/
noun
noun: rennin
an enzyme secreted into the stomach of unweaned mammals causing the curdling of milk.
Origin
- - -
11.
chelating:
A chemical compound that binds tightly to metal ions. In medicine, chelating agents are used to remove toxic metals from the body.
- - -
Weak Kidney - What to do
Weak kidneys? Pay attention but don't worry excessively
Many older men have low-normal kidney function, but it doesn't need to become a serious health threat.
Chronic kidney disease means the kidneys—the body's blood-filtering urine factory—have less capacity to filter toxins from the blood and excrete them in the urine. Half of U.S. adults over 75 may have below-normal kidney function, but most of them will never get sick from it. In men whose kidney function is falling, certain steps can help to slow or prevent further losses.
"Kidney function appears to decline with age in some people, but it does not necessarily cause a problem unless you have other health conditions," says Dr. Melanie Hoenig, an assistant professor of medicine at Harvard-affiliated Joslin Diabetes Center.
What causes it?
Every day, a healthy kidney filters a total of about 200 quarts of blood, removing waste products, excess water, and certain chemicals. If the kidneys didn't keep things in balance, you would slowly poison yourself.
The kidneys have a remarkable ability to keep working despite changing conditions, like drops in blood pressure. The tiny filtering tubes in the kidney, called glomeruli, adapt in various ways.
In a serious health crisis, the kidneys may shut down completely as a defensive move to keep fluids in the body. That's called an acute kidney injury, and it happens frequently to people who are hospitalized.
Smoking, excessive alcohol consumption, high blood pressure, and high blood sugar (diabetes) all harm the kidneys and can lead to chronic kidney disease. If you are leading a heart-healthy lifestyle (regular exercise and a nutritious plant-based diet), that will help protect your kidneys.
How low is low?
A healthy kidney filters wastes from the blood at a rate of 90 milliliters (ml) per minute or more. This is known as the glomerular filtration rate, or GFR. With time, many men's kidneys start to slip, but function must decline quite a lot before you start to really feel the impact. "You feel fine up to the point that kidney function is almost gone, which means you can lead a normal life with reduced kidney function," Dr. Hoenig says.
On the other hand, lack of early warning from symptoms can deny you the chance to slow the slide. "Most people don't start feeling really ill until kidney function is under 10%," Dr. Hoenig says.
How is it tested?
As part of standard blood tests, your doctor may check the level of a protein called creatinine. This provides a way to assess kidney function.
Creatinine is one of the things that the kidneys filter from the blood. If the kidneys start to fail, creatinine rises. The creatinine level is used to calculate an estimate of the GFR and provide an estimate of your kidney function. It is often just an estimate because the formulas doctors use are not accurate when the kidney function is close to normal.
At different levels of kidney function, individuals tend to have similar problems. But once a person reaches a certain stage of reduced kidney function, he may be stable and never progress to the next stage. If the function is low but stable, you may not need to see a doctor about it—providing you are leading a healthy life and doing well. "If the GFR is declining and already under 50, I think it would be a good idea to see a kidney doctor, if for no other reason than to become educated," Dr. Hoenig says.
How high blood pressure damages the kidneysHigh blood pressure can cause tiny cracks in the lining of arteries, which provide a breeding ground for fatty deposits that hamper blood flow. As the arteries that feed blood to the kidneys narrow, the body produces renin, a hormone that makes small arteries narrow further. This worsens high blood pressure, causing even more kidney damage. Over time, restricted blood flow can damage or destroy the nephrons, the tiny filtering units inside your kidneys. |
Protecting your kidneys
If kidney function begins to slide, men are not powerless against it. Here are some steps you can take:
Keep your blood pressure and blood sugar within norms. This will help slow the decline in kidney function. Especially, keep blood pressure below 130/80.
Lower your cholesterol. Taking a statin medication to lower "bad" LDL cholesterol may help to protect the kidneys. Also, individuals with reduced kidney function are at greater risk for cardiovascular disease, so reducing cardiac risk factors is important.
Consider medication. Certain prescription medications can protect the kidneys. The two that physicians often use for this purpose are ACE inhibitors (also commonly prescribed for high blood pressure) and angiotensin-receptor blockers (ARBs). These or other drugs can lower pressure in the kidney filters and limit further damage.
Limit protein intake. Eating too much protein can strain weak kidneys. Limit your protein intake every day to no more than 1 gram per kilogram (2.2 pounds) of body weight. Consulting with a dietitian can help you plan meals that are safe for weak kidneys.
Use NSAIDs with caution. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, interfere with kidney function. Taking them when you are also depleted of fluids can lead to kidney shutdown and possibly hospitalization. Drink plenty of water when you are using NSAIDs. As kidney function declines, doses of other medication may need to be reduced to prevent kidney damage, including antibiotics, diabetes drugs, and some heart medications.
Folliserum Ingredients (Apr 2021)
1. Aqua Aqua: water, when it is used in make-up and beauty products 2. Butylene glycol Butylene glycol is a chemical ingredient used in self-care products like: 2.1. shampoo 2.2. conditioner 2.3. lotion 2.4. anti-aging and hydrating serums 2.5. sheet masks 2.6. cosmetics 2.7. sunscreen Butylene glycol is included in formulas for these types of products because it adds moisture and conditions hair and skin. It also works as a solvent, meaning it keeps other ingredients, dyes, and pigments from clumping up inside of a solution. Like all glycols, butylene glycol is a type of alcohol. It’s often made from distilled corn. There are some health concerns that surround the use of butylene glycol. Some experts warn against its use, and cite it on lists of ingredients to avoid when choosing self-care products. The risk in using butylene glycol is still somewhat unclear. More research is needed to understand how it can affect your body in the long term. Butylene glycol uses Butylene glycol is added to all kinds of products that you apply topically. It’s particularly popular in clear gel-based products and in makeup that glides onto your face. You’ll find it on the ingredients list of sheet masks, shampoos and conditioners, eye liners, lip liners, anti-aging and hydrating serums, tinted moisturizers, and sunscreens. Butylene glycol is a viscosity-decreasing agent “Viscosity” is a word that refers to how well things stick together, particularly in a compound or chemical mixture. Butylene glycol makes other ingredients less likely to stick together, giving makeup and self-care products a fluid and even consistency. Butylene glycol is a conditioning agent Conditioning agents are ingredients that add a layer of softness or improved texture to your hair or skin. They’re also called moisturizers or, in the case of butylene glycol, humectants. Butylene glycol works to condition skin and hair by coating the surface of your cells. Butylene glycol is a solvent Solvents are ingredients that maintain a liquid consistency in a chemical compound. They help active ingredients that could become gritty or clumpy stay dissolved. Butylene glycol keeps the ingredients in cosmetics spread out and in their desired state for use. Butylene glycol benefits Butylene glycol has some health benefits if you have dry skin on your face or frequent breakouts. But it won’t work the same way for every person. Generally, most people who have dry skin can use products with butylene glycol to reduce their symptoms. Butylene glycol for acne Butylene glycol is in some moisturizersTrusted Source made for people who have acne. It isn’t the active ingredient that treats acne in these products. The moisturizing and solvent properties in butylene glycol could make these products right for you. However, there are reports of this ingredient clogging pores or irritating skin and actually making acne worse. Based on your symptoms, the cause of your acne, and your skin sensitivity, butylene glycol may be an ingredient that works in your skin care regimen. Ref: healthline 3. ppg-26-buteth-26 What Is It? Polypropylene Glycol (PPG) Buteths (PPG-12-Buteth-16, PPG-9-Buteth-12, PPG-26-Buteth-26, PPG-28-Buteth-35) are colorless or pale yellow, transparent liquids. In cosmetics and personal care products, PPG Buteth ingredients are used in the formulation of bubble baths and other bath products, shampoos and other hair products, skin fresheners, skin cleansers, and shaving products. Why is it used in cosmetics and personal care products? PPG Buteth ingredients enhance the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment. They also enhance the appearance of dry or damaged skin by reducing flaking and restoring suppleness. PPG Buteths help to form emulsions by reducing the surface tension of the substances to be emulsified. PPG-12-Buteth-16 can also be used to dissolve other substances, usually liquids. Scientific Facts: PPG Buteth ingredients are synthetic polymers prepared from small chemical compounds called monomers. PPG Buteths are made from equal amounts ethylene oxide and propylene oxide monomers, and the reaction is initiated by the addition of butyl alcohol. The first number in the name indicates the average number of units of propylene oxide, while the second number indicates the average number of units of ethylene oxide. Ref: cosmeticsinfo 4. PEG 40 Hydrogenated Castor Oil WHAT IS PEG 40 HYDROGENATED CASTOR OIL? PEG 40 Hydrogenated Castor Oil is the Polyethylene Glycol derivatives of Hydrogenated Castor Oil, and it functions as a surfactant, a solubilizer, an emulsifier, an emollient, a cleansing agent, and a fragrance ingredient when added to cosmetics or personal care product formulations. NDA’s PEG 40 Hydrogenated Castor Oil is a semi-solid ingredient. surfactant: a substance which tends to reduce the surface tension of a liquid in which it is dissolved. solubilizer: an agent that increases the solubility of a substance. emulsifier: An emulsifier is an additive which helps two liquids mix. For example, water and oil separate in a glass, but adding an emulsifier will help the liquids mix together. Some examples of emulsifiers are egg yolks and mustard. emollient: Emollients are substances that soften and moisturize the skin and decrease itching and flaking. HOW DOES PEG 40 HYDROGENATED CASTOR OIL WORK? PEG-40 Hydrogenated Castor Oil is soluble in both water and oil and is traditionally used to emulsify and solubilize oil-in-water formulations. Its foam-enhancing properties make it ideal for use in liquid cleansers, and its soothing and softening emollient quality makes it a popular addition to formulations for moisturizers and hair care cosmetics. As a surfactant, PEG 40 Hydrogenated Castor Oil helps to decrease the surface tension between multiple liquids or between liquids and solids. Furthermore, it helps to remove the grease from oils and causes them to become suspended in the liquid. This makes it easier for them to be washed away and lends this ingredient popularity in facial and body cleansers. As an occlusive agent, PEG 40 Hydrogenated Castor Oil creates a protective hydrating layer on the skin’s surface, acting as a barrier against the loss of natural moisture. Ref: newdirectionsaromatics 5. Apigenin One of the bioflavonoids, apigenin appears to be catered towards reducing anxiety and causing sedation. Found in chamomile tea, alcoholic beverages, and Bacopa Monnieri, apigenin is unstable by itself yet stable when consumed via foods and herbs. [Ref: examine] The Therapeutic Potential of Apigenin Chronic diseases, such as cancer, stroke, diabetes, Alzheimer’s disease, depression, and age-related function decline, are major public health burdens worldwide, especially in developed countries. It is believed that a combination of regular physical activity and healthy diet can prevent these various diseases, as well as help in fighting already existing diseases. Particular attention has been paid to a diet based on fruits and vegetables, which are sources of natural bioactive compounds with pro-health properties. The largest group of naturally-occurring polyphenols are the flavonoids, which include flavones, flavonols, flavanones, flavanols, isoflavonoids, and anthocyanidins. Flavonoids are characterized by broad biological activities, demonstrated in numerous mammalian systems in vitro and in vivo. These compounds act as free-radical scavengers and antioxidants, exhibiting anti-mutagenic, anti-inflammatory, and antiviral effects. What is more, flavonoids are able to reduce plasma levels of low-density lipoproteins, inhibit platelet aggregation, and reduce cell proliferation. These properties result, inter alia, from their mechanisms of action: inhibiting the cell cycle, diminishing oxidative stress, improving detoxification enzymes, inducing apoptosis, and stimulating the immune system. Of all the flavonoids, apigenin (4′,5,7-trihydroxyflavone) is one of the most widely distributed in the plant kingdom, and one of the most studied phenolics. Apigenin is present principally as glycosylated in significant amount in vegetables (parsley, celery, onions) fruits (oranges), herbs (chamomile, thyme, oregano, basil), and plant-based beverages (tea, beer, and wine). The present review is focused on the health-promoting effects of apigenin, in particular through in vivo research. Ref: US National Library of Medicine; National Institutes of Health Chemically: Apigenin (4′,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. It is a yellow crystalline solid that has been used to dye wool. [Ref: Wikipedia] 6. Oleanolic acid Oleanolic acid is relatively non-toxic, hepatoprotective, and exhibits antitumor and antiviral properties. Oleanolic acid was found to exhibit weak anti-HIV and weak anti-HCV activities in vitro, but more potent synthetic analogs are being investigated as potential drugs. An extremely potent synthetic triterpenoid analog of oleanolic acid was found in 2005, that is a powerful inhibitor of cellular inflammatory processes. They work by the induction by IFN-γ of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages. They are extremely potent inducers of the phase 2 response (e.g., elevation of NADH-quinone oxidoreductase and heme oxygenase 1), which is a major protector of cells against oxidative and electrophile stress. A 2002 study in Wistar rats found that oleanolic acid reduced sperm quality and motility, causing infertility. After withdrawing exposure, male rats regained fertility and successfully impregnated female rats. [Ref: Oleanolic acid] Oleanolic acid is a pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3. It has a role as a plant metabolite. It is a pentacyclic triterpenoid and a hydroxy monocarboxylic acid. It is a conjugate acid of an oleanolate. It derives from a hydride of an oleanane. Ref: National Center for Biotechnology Information; National Library of Medicine; National Institutes of Health; Department of Health and Human Services; USA.gov 7. Biotinoyl Tripeptide-1 What-it-does: cell-communicating ingredient A three amino acid peptide where the famous collagen fragment, Tripeptide-1, aka GHK is combined with Biotin, the well-known supplement for stronger nails and hairs. The result of the combination is Biotinoyl Tripeptide-1, a peptide claimed to be helpful for reducing hair loss and for making the eyelashes appear longer, fuller, and stronger. As for proof, the manufacturer did some in-vitro (made in test tubes) studies that show that our molecule can promote hair bulb keratinocyte proliferation and also helps optimal hair anchorage by stimulating the synthesis and organization of the adhesion molecules laminin 5 and collagen IV. This means that our peptide might help the hair to be stronger and to stay longer in its place, though these are only in vitro results that might or might not translate to real-world use. Ref: incidecoder 8. Polysorbate 20 Polysorbate 20 is an ingredient used in skincare and cosmetic formulations to improve the texture, feel, and scent of the product. It is mainly used as a surfactant, emulsifier, and fragrance ingredient. Polysorbate 20, also listed on an ingredient label as Tween 20, is formed by the ethoxylation of sorbitan before the addition of lauric acid. The process of making polysorbate 20 begins with sorbitol, a sugar alcohol that can naturally be found in some fruits. The dehydration of sorbitol results in sorbitan. The next step in the process of making polysorbate 20 is ethoxylation, which is a chemical reaction in which ethylene oxide is added to a substrate, in this case, sorbitan. Thus, sorbitan is reacted with 20 units of ethylene oxide, giving polysorbate 20 its name. The final step is the addition of one lauric acid group. Polysorbate 20 is used in a variety of cosmetics and skincare products including cleansers, makeup bases and foundations, shampoos, fragrances, and more. This ingredient exists in the form of a clear to a light yellow viscous liquid. Ref: thedermreview 9. Glycerin Behind water and fragrance, glycerin is the third most frequently reported ingredient in cosmetics, according to a 2014 Cosmetic Ingredient Review. Recognized as a major ingredient in moisturizers and lotions, buying and using glycerin in its pure form is growing in popularity. Studies show that glycerin can positively affect your skin in a number of ways. Keep reading to find out how. Glycerin and your skin Glycerin’s appearance in skin care products appears to be warranted. According to a 2008 study, glycerin can: 9.1. hydrate the outer layer of the skin (stratum corneum) 9.2. improve skin barrier function and skin mechanical properties 9.3. provide protection against skin irritants 9.4. accelerate wound-healing processes Ref: healthline 10. PEG-12 Dimethicone PEG-12 Dimethicone is a silicone glycol copolymer that is soluble in water, alcohol, and hydro-alcoholic systems. It acts as a surface tension depressant, wetting agent, emulsifier and foam builder to create and sustain foam in a high alcohol-content hand sanitizer formulations. PEG-12 Dimethicone is also used in in a wide variety of cosmetic and personal care products, including, hair sprays, shampoos, skin care, lotions, perfumes and shaving soaps, to create and sustain foam. Ref: clearcoproducts 11. Polyquaternium-22 Polyquaternium is the International Nomenclature for Cosmetic Ingredients designation for several polycationic polymers that are used in the personal care industry. Polyquaternium is a neologism used to emphasize the presence of quaternary ammonium centers in the polymer. INCI has approved at least 40 different polymers under the polyquaternium designation. Different polymers are distinguished by the numerical value that follows the word "polyquaternium". Polyquaternium-5, polyquaternium-7, and polyquaternium-47 are three examples, each a chemically different type of polymer. The numbers are assigned in the order in which they are registered rather than because of their chemical structure. Polyquaterniums find particular application in conditioners, shampoo, hair mousse, hair spray, hair dye, personal lubricant, and contact lens solutions. Because they are positively charged, they neutralize the negative charges of most shampoos and hair proteins and help hair lie flat. Their positive charges also ionically bond them to hair and skin. Some have antimicrobial properties. Ref: Polyquaternium 12. Niacinamide What is Niacinamide? Niacinamide is a water soluble-form of vitamin B3 that has many benefits suited to any and all skin and hair types. Niacinamide benefits Niacinamide is an antioxidant and anti-inflammatory ingredient. It can help brighten and refresh skin and hair by helping to retain moisture. It can also help regulate oil for more refreshed and balanced-feeling scalp and skin. Niacinamide for hair Niacinamide has a vital role in growing long and strong hair due to its circulation boosting properties. It enhances the appearance and feel of hair, by increasing body, suppleness, sheen. It also improves the texture of hair that has been physically/chemically damaged by helping to build Keratin. It also enhances the appearance of dry or damaged skin on the scalp by reducing flaking and restoring suppleness. Ref: growgorgeous 13. Helianthus Annuus (Sunflower) Seed Extract Sunflower oil benefits for hair and skin: (helianthus annuus): Besides being a beautiful gift of nature and used passionately by artists, sunflowers contain significant properties for great skin and hair. Rich in nutrients such as calcium, iron, magnesium, zinc and vitamins A, K and E, it’s used effectively against inflammation and general irritations of the skin. Being very high in vitamin E, it acts as an emollient which traps moisture and keeps skin well hydrated. It also helps prevent damage to cells by ultraviolet light and aids against premature aging of skin by protecting the collagen and elastin content. Sunflower is a source for beta-carotene which is converted to vitamin A with benefits of protection from sun damage and free radicals. Omega-6 (linoleic acid) which is found in sunflower oil, assists with cell development and treating disorders such as eczema, acne and scarring. A number of characteristics make sunflower oil also beneficial for hair. The linoleic acid it contains assists with slowing hair loss. The menthol assists with dandruff control while its antibacterial properties help keep the scalp microbial free. Its emollient properties keep hair soft, moist and assist with untangling. So when driving by a gorgeous field of sunflowers on a European Summer or see an old man chipping away on sunflower seeds in a village, remember the positive effects it has on our bodies for health and protection. Aeolis uses sunflower oil in its body lotions, hand cream, hair conditioner, hair mask and anti-wrinkle lifting face cream. Ref: aeolisskincare 14. Pea Protein Powder Pea protein powder is a supplement made by extracting protein from yellow peas. It’s typically used to increase the protein content of smoothies and shakes and is a great fit for almost any diet since it’s naturally vegan and hypoallergenic. Pea protein is a high-quality protein and a great source of iron. It can aid muscle growth, weight loss and heart health. This article reviews the nutrition, health benefits and possible side effects of pea protein powder. Pea protein powder — or pea protein isolate — is made by isolating the protein from ground yellow peas, forming a beige powder. Nutrition facts can vary between brands, but — for example — two scoops (20 grams) of NOW Organic Pea Protein Powder contains: 14.1. Calories: 80 14.2. Protein: 15 grams 14.3. Carbs: 1 gram 14.4. Fiber: 1 gram 14.5. Total fat: 1.5 grams 14.6. Sodium: 230 mg 14.7. Iron: 5 mg Pea protein powders offer a variety of nutritional benefits. Ref: healthline 15. PEG-8 What-it-does: moisturizer/humectant, solvent A smallish polymer molecule (created from repeated units of Polyethylene glycol, aka PEG) that's used as a solubilizer and viscosity control agent. It is a clear, colorless liquid that is water-soluble and water-binding (aka humectant) and can help to solubilize sparingly-water soluble things (e.g. vanilla, perfumes) into water-based formulas. Thanks to its water-binding ability, it also prevents the drying out of formulas, especially when combined with the fellow hygroscopic agent, sorbitol. Ref: incidecoder 16. PEG-8/SMDI COPOLYMER 17. PALMITOYL MYRISTYL SERINATE Palmitoyl Myristyl Serinate is a product obtained by the condensation of Palmitic Acid (q.v.)with Serine (q.v.), followed by esterification with Myristyl Alcohol (q.v.). Skin-conditioning agent: miscellaneous and skin conditioning Ref: ewg.org 18. Sodium polyacrylate Sodium polyacrylate (also called acrylic sodium salt polymer) is a superabsorbent polymer that is used extensively in commercial applications as a water absorbent. It is a white, granular, odorless solid that is not considered hazardous. Sodium polyacrylate is made when a mixture of acrylic acid and sodium acrylate is polymerized. Ref: sciencing Sodium polyacrylate is an absorbent polymer that is used as an emulsion stabilizer, a hair fixative, a film former, skin conditioner, and a viscosity agent. You will see them as the gel like crystals in baby diapers, which are makes them absorbent. In detergents it works as a chelating agent, which neutralizes the heavy metals in water & dirt so that the detergent can be more effective at cleaning. It is also used as a thickening agent because it can absorb and hold onto water molecules. Ref: forceofnatureclean 19. Adenosine Adenosine in the brain In the brain adenosine is an inhibitory neurotransmitter. This means, adenosine can act as a central nervous system depressant. In normal conditions, it promotes sleep and suppresses arousal. When awake the levels of adenosine in the brain rise each hour. Adenosine in the heart In the heart adenosine causes dilation of the coronary blood vessels that improves blood circulation to the heart. Adenosine also increases the diameter of blood vessels in the peripheral organs. In the heart adenosine decreases heart rate and in blood it has an anti-platelet action. Antiplatelet action prevents platelet aggregation and coagulation. Adenosine in the kidneys, lungs and liver In the kidneys, adenosine decreases renal blood flow and decrease the production of rennin from the kidneys. In the lungs, it causes constriction of airways and in the liver it leads to constriction of blood vessels and increases breakdown of glycogen to form glucose. Ref: Adenosine 20. Phenoxyethanol Why is it added to cosmetics? In perfumes, fragrances, soaps, and cleansers, phenoxyethanol works as a stabilizer. In other cosmetics, it’s used as an antibacterial and/or a preservative to prevent products from losing their potency or spoiling. When combined with another chemical, some evidence indicates that it’s effective at reducing acne. One 2008 study on 30 human subjects with inflammatory acne showed that after six weeks of twice-daily applications, more than half of the subjects saw a 50 percent improvement in their number of pimples. Manufacturers who want to avoid using parabens, which have recently lost favor among health-conscious consumers, might use phenoxyethanol in their products as a substitute. But is phenoxyethanol safer than parabens for topical use in humans? Ref: healthline 21. Ethylhexylglycerin Ethylhexylglycerin is a globally approved, versatile and multifunctional additive as well as a very effective deodorant active. As an emollient and mild humectant it improves the skin feel of cosmetic formulations. It reliably inhibits the growth and multiplication of odour-causing bacteria, while at the same time not affecting the beneficial skin flora. Additionally, it can boost the efficacy of traditional preservatives and acts as an antimicrobial stabiliser in combination with other cosmetic ingredients. Ref: ethylhexylglycerin 22. Cocos Nucifera oil There is definitely some craze going on for coconut oil both in the healthy eating space (often claimed to be the healthiest oil to cook with but this is a topic for another site) and in the skin and hair care space. We will talk here about the latter two and see why we might want to smear it all over ourselves. Chemically speaking, coconut oil has a unique fatty acid profile. Unlike many plant oils that mostly contain unsaturated fatty acids (fatty acids with double bonds and kinky structure such as linoleic or oleic), coconut oil is mostly saturated (fatty acids with single bonds only) and its most important fatty acid is Lauric Acid (about 50%). Saturated fatty acids have a linear structure that can stack nice and tight and hence they are normally solid at room temperature. Coconut oil melts around 25 °C so it is solid in the tub but melts on contact with the skin. Ref: incidecoder 23. Hydroxyethyl cellulose Hydroxyethyl cellulose is a gelling and thickening agent derived from cellulose. It is widely used in cosmetics, cleaning solutions, and other household products. Hydroxyethyl cellulose and methyl cellulose are frequently used with hydrophobic drugs in capsule formulations, to improve the drugs' dissolution in the gastrointestinal fluids. This process is known as hydrophilization. Hydroxyethyl cellulose is also used extensively in the oil & gas industry as a drilling mud additive under the name HEC as well in industrial applications, paint & coatings, ceramics, adhesives, emulsion polymerization, inks, construction, welding rods, pencils and joint fillers. Hydroxyethyl cellulose is one of the main ingredients in the personal lubricant KY Jelly. It is also a key ingredient in the formation of big bubbles as it possesses the ability to dissolve in water but also provide structural strength to the soap bubble. Among other similar chemicals, it is often used as slime (and gunge, in the UK), a gooey substance often used on television and in fundraising events which is poured over individuals with the aim of causing embarrassment. Ref: Hydroxyethyl cellulose 24. Melatonin Melatonin is a hormone found naturally in the body. Melatonin used as medicine is usually made synthetically in a laboratory. It is most commonly available in pill form, but melatonin is also available in forms that can be placed in the cheek or under the tongue. This allows the melatonin to be absorbed directly into the body. Some people take melatonin by mouth to adjust the body's internal clock. Melatonin is most commonly used for insomnia and improving sleep in different conditions. For example, it is used for jet lag, for adjusting sleep-wake cycles in people whose daily work schedule changes (shift-work disorder), and for helping people establish a day and night cycle. Coronavirus disease 2019 (COVID-19): There is no good evidence to support using melatonin for COVID-19. Follow healthy lifestyle choices and proven prevention methods instead. How does it work? Melatonin's main job in the body is to regulate night and day cycles or sleep-wake cycles. Darkness causes the body to produce more melatonin, which signals the body to prepare for sleep. Light decreases melatonin production and signals the body to prepare for being awake. Some people who have trouble sleeping have low levels of melatonin. It is thought that adding melatonin from supplements might help them sleep. Ref: webmd 25. Disodium EDTA A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive. Chelating: A chemical compound that binds tightly to metal ions. In medicine, chelating agents are used to remove toxic metals from the body. Ref: pubchem.ncbi.nlm.nih.gov 26. Cholecalciferol Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D which is made by the skin when exposed to sunlight; it is also found in some foods and can be taken as a dietary supplement. Cholecalciferol is made in the skin following UVB light exposure. It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25-dihydroxyvitamin D). One of its actions is to increase the uptake of calcium by the intestines. It is found in food such as some fish, beef liver, eggs, and cheese. Certain foods such as milk, fruit juice, yogurt, and margarine also may have cholecalciferol added to them in some countries including the United States. Cholecalciferol can be taken as an oral dietary supplement to prevent vitamin D deficiency or as a medication to treat associated diseases, including rickets. It is also used for familial hypophosphatemia, hypoparathyroidism that is causing low blood calcium, and Fanconi syndrome. Vitamin-D supplements may not be effective in people with severe kidney disease.[9][8] Excessive doses in humans can result in vomiting, constipation, weakness, and confusion. Other risks include kidney stones. Doses greater than 40,000 IU (1,000 μg) per day are generally required before high blood calcium occurs. Normal doses, 800–2000 IU per day, are safe in pregnancy. Cholecalciferol was first described in 1936. It is on the World Health Organization's List of Essential Medicines. Cholecalciferol is available as a generic medication and over the counter. Cholecalciferol is also used at much higher doses to kill rodents. Ref: Cholecalciferol Vitamin D (ergocalciferol-D2, cholecalciferol-D3, alfacalcidol) is a fat-soluble vitamin that helps your body absorb calcium and phosphorus. Having the right amount of vitamin D, calcium, and phosphorus is important for building and keeping strong bones. Vitamin D is used to treat and prevent bone disorders (such as rickets, osteomalacia). Vitamin D is made by the body when skin is exposed to sunlight. Sunscreen, protective clothing, limited exposure to sunlight, dark skin, and age may prevent getting enough vitamin D from the sun.Vitamin D with calcium is used to treat or prevent bone loss (osteoporosis). Vitamin D is also used with other medications to treat low levels of calcium or phosphate caused by certain disorders (such as hypoparathyroidism, pseudohypoparathyroidism, familial hypophosphatemia). It may be used in kidney disease to keep calcium levels normal and allow normal bone growth. Vitamin D drops (or other supplements) are given to breast-fed infants because breast milk usually has low levels of vitamin D. Ref: webmd Other Notes Folliserum: 60 ML bottle lasts for lesser than a month and costs around 1200 INR as in Mar 2021.
Sunday, April 11, 2021
Are NSAIDs bad for liver and kidney?
How much ibuprofen can I take? To treat mild to moderate pain, minor fever, and acute or chronic inflammation, 200 mg to 400 mg of ibuprofen will work. That amount is comparable to 650 mg of acetaminophen (Tylenol) or aspirin. Generally, the maximum amount of NSAIDs you should take per day is 3200 mg or 12 over-the-counter tablets. That means if you take a dose every 6 hours, you can take up to 800 mg each time. - - - Can ibuprofen cause liver damage? Ibuprofen and other NSAIDs rarely affect the liver. Unlike acetaminophen (Tylenol), most NSAIDs are absorbed completely and undergo negligible liver metabolism. In other words, the way NSAIDs are metabolized makes liver injury ( hepatotoxicity) very rare. Estimates are that 1 to 9 in 100,000 NSAID prescriptions result in acute liver injury. Generally, NSAIDs are very liver-safe. However, if you have problems with your liver, such as cirrhosis, talk to your doctor before taking NSAIDs. Also, studies have shown NSAIDs can cause elevated results on liver tests in up to 15% of patients. - - - Is ibuprofen bad for my kidneys? While NSAIDs rarely affect the liver, they have important adverse effects on the kidneys that you should know about. Here is the science behind the problem. Ibuprofen and other NSAIDs block prostaglandins, natural body chemicals that normally dilate blood vessels leading to the kidneys. Blocking prostaglandins may lead to decreased blood flow to the kidneys, which means a lack of oxygen to keep the kidneys alive. That can cause acute kidney injury. Acute kidney injury can occur with any NSAID, though naproxen seems to be a bigger culprit. In one study, folks who took NSAIDs had twice the risk of acute kidney injury within 30 days of starting to take the medications. People with existing kidney problems more often get in trouble. The good news is these effects are reversible if you stop taking NSAIDs. Remember, acute kidney injury from NSAIDs doesn’t cause any symptoms. if you are taking ibuprofen for long periods of time, it’s not a bad idea to have a check of your kidney function with a quick blood test. The test may show a rise in creatinine if your kidneys are being affected, usually seen within the first 3 to 7 days of NSAID therapy. - - - Ibuprofen and other NSAIDs block prostaglandins, natural body chemicals that normally dilate blood vessels leading to the kidneys. Blocking prostaglandins may lead to decreased blood flow to the kidneys, which means a lack of oxygen to keep the kidneys alive. That can cause acute kidney injury. Are NSAIDs Like Ibuprofen Bad for My Liver and Kidneys?
Biotin with L-Cysteine and Mineral Tablets
Biotin with L-Cysteine and Mineral Tablets Pricing: 97.50 INR (March 2021) Biotin is a vitamin. Foods such as eggs, milk, or bananas contain small amounts of biotin. Biotin is used for biotin deficiency. It is also commonly used for hair loss, brittle nails, and other conditions, but there is no good scientific evidence to support these uses. How does it work ? Biotin is an important component of enzymes in the body that break down certain substances like fats, carbohydrates, and others. There isn't a good laboratory test for detecting low biotin levels, so this condition is usually identified by its symptoms, which include thinning of the hair (frequently with loss of hair color) and red scaly rash around the eyes, nose, and mouth. Other symptoms include depression, tiredness, hallucinations, and tingling of the arms and legs. There is some evidence that diabetes could cause low biotin levels. Biotin - - - L-Cysteine: Potent anti-oxidant protection to the hair follicle, facilitate longer hair growth. L-cysteine is a semi-essential amino acid found naturally in the human body. Abundant in protein-rich foods, L-cysteine is also sold as a dietary supplement (sometimes just called cysteine). Along with the amino acids glutamine and glycine, cysteine is a building block of the powerful antioxidant glutathione. The body can make cysteine from the amino acids methionine and serine, but if these are in short supply, supplementing with L-cysteine can fill the gaps. Among the uses promoted for L-cysteine are the easing of flu symptoms, the treatment of certain inflammatory diseases, and the management of diabetes. In alternative medicine, L-cysteine is used as a natural treatment for: 1. Angina 2. Cardiovascular disease 3. Chronic bronchitis 4. Diabetes 5. Flu 6. Inflammation 7. Inflammatory bowel disease 8. Osteoarthritis 1: 1mg 2: verywellhealth.com
Volflam Plus (Diclofenac Sodium and Paracetamol)
Volflam Plus Pricing: 25 INR (March 2021) Uses Diclofenac+Paracetamol is used for pain relief. It relieves pain in conditions like: 1. headache 2. mild migraine 3. muscle pain 4. dental pain 5. rheumatoid arthritis 6. ankylosing spondylitis 7. osteoarthritis, or 8. painful menses Common Side Effects Side Effects of Volflam Plus are: 1. Nausea 2. Vomiting 3. Stomach pain/epigastric pain 4. Heartburn 5. Diarrhea 6. Loss of appetite Mechanism of action These medicines work by blocking the action of chemical messengers responsible for: 1. pain 2. fever and 3. inflammation (redness and swelling) Q: Can the use of Volflam Plus 50 mg/325 mg Tablet cause damage to kidneys? Ans: Yes, the long-term use of Volflam Plus 50 mg/325 mg Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protect them from damage. Use of painkillers lowers the levels of prostaglandins in the body leading to kidney damage on long-term use. Use of painkillers is not recommended in patients with underlying kidney disease. Q: Are there any specific contraindications associated with the use of Volflam Plus 50 mg/325 mg Tablet? Ans: The use of Volflam Plus 50 mg/325 mg Tablet is considered to be harmful in patients with known allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or in patients with active, recurrent stomach ulcer/bleeding. It should also be avoided in patients with the history of heart failure, high blood pressure, and liver or kidney disease. [ Ref ] Other notes 1. Related to 'Ankylosing Spondylitis': HLA-B27 is a blood test to look for a protein that is found on the surface of white blood cells. The protein is called human leukocyte antigen B27 (HLA-B27). Human leukocyte antigens (HLAs) are proteins that help the body's immune system tell the difference between its own cells and foreign, harmful substances. 2. Paracetamol, also known as acetaminophen, is widely used as an analgesic and antipyretic drug. An acute paracetamol overdose can lead to potentially lethal liver and kidney failure in humans and experimental animals and in severe cases to death. Paracetamol-Induced Renal Tubular Injury: A Role for ER Stress
Subscribe to:
Comments (Atom)